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Description
Alexa Fluor® 647 Mouse Anti-Human CD137 Antibody (S-2851)Product Specification Host Mouse Antigen CD137 Synonyms Tumor necrosis factor receptor superfamily member 9; 4 1BB ligand receptor; CDw137; T cell antigen 4 1BB homolog; T cell antigen ILA; ILA; TNFRSF9 Location Cell membrane Accession Q07011 Clone Number S 2851 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Mouse |
| Antigen | CD137 |
| Synonyms | Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; ILA; TNFRSF9 |
| Location | Cell membrane |
| Accession | Q07011 |
| Clone Number | S-2851 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD137, also known as 4-1BB, is a co-stimulatory molecule expressed on the surface of activated T cells and natural killer cells. It plays a crucial role in enhancing the immune response by providing additional signals that promote T cell proliferation, survival, and cytokine production. CD137 is a member of the tumor necrosis factor receptor superfamily and its ligand, CD137L, is primarily found on antigen-presenting cells. The interaction between CD137 and CD137L helps to sustain the activation of T cells and supports the development of long-lasting immune responses, making it an important target for immunotherapy in cancer treatment and other diseases where modulation of the immune system is beneficial.
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4.4 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 5
Minty & Whitening Approved!
Size: 4 Ounce (Pack of 4), Set name: Adult Mint
MY FAVORITE fluoride free toothpaste. I still get that slight minty fresh taste and has effectively whitened my teeth as people have noticed and complimented me on.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 1, 2026
★★★★★ 5
Phenomenal NHa toothpaste
Size: 4 Ounce (Pack of 1), Set name: Adult Mint
I am fluoride free. It’s toxic AND did you know it oxidizes the tooth from the inside out and actually MAKES your TEETH YELLOW!? Crest even admitted it. Fluorides risks outweigh the teeth benefits but LUCKILY there’s a more superior solution: nano hydroxyapatite for our teeth remineralization needs. It’s safe and proven to be more effective as a remineralizing agent, unlike fluoride which cannot remineralize on its own - it requires the minerals in your saliva to work, so if your saliva isn’t at the optimal levels, it’s useless to teeth. But I have been on a teeth whitening journey - got my teeth whitened at my dentist but I ate a tangerine and they got stained again. (Stupid me. Bye $325!) While I’ve restored the whiteness back with various at home products, it’s been at the expense of my enamel and has caused a lot of sensitivity. Sensodyne was given to me by my dentist but when I saw it visibly yellow my teeth after the dentist’s first bleaching, I went down a rabbit hole to get to the bottom of it as to why. Additionally, my enamel has been getting more and and more clear, and I needed this to be addressed. NHa has been proven to restore enamel which treats tooth sensitivity instead of just numbing the nerves with potassium nitrate like Sensodyne does which treats the symptom and not the cause (tooth demineralization, sigh… such a western medicine move). When I bought this for the first time I was immediately pleased - there’s NO scary flavor (if you’ve ever tried *natural* toothpastes, especially ones of India, You KNOW!). There’s no cardamom or other cinnamon or out of the ordinary flavors here. The consistency is that of normal toothpaste. Great foaming action. Has helped my sensitivity in 2 applications, I’m 100% without sensitivity but even better, my teeth my are less clear. This truly restores enamel.
But, here’s my gripes. #1 - I have no idea how much hydroxyapatite is in this. I know it works, but as a consumer, I deserve to know what % of the star ingredient is used in a product that I’m specifically buying it for.
#2 - the toothpaste color is… lightish yellow. Think a healthy “mucus yellow” - I’m so sorry for the that description, but when I spit up bits of toothpaste in my sink, it looks like boogers. That’s an issue when I’m busy whitening my teeth at home & I’m avoiding eating foods that stain teeth for at least 2 hours after so that my saliva can naturally seal my dental pores that are being blasted open with peroxide. If I brush my teeth after whitening I’m extremely paranoid that I’m pushing YELLOW toothpaste into my porous teeth, and I don’t need to keep driving myself crazy thinking that the NHa is potentially sealing that color in. I also want to be able to put my NHa toothpaste in clean whitening trays to give myself a mineralizing treatment without worrying about it staining my teeth from prolonged/concentrated contact. Mind you - this is very paranoid of me to think, but I’ve spent a lot fixing my teeth bleaching then restaining fiasco, so I’m not taking any chances. While I don’t think it’s yellowing my teeth at all, because of the color, I’ll never think it’s whitening them.
But don’t let this deter you from purchasing. It helps sensitivity after one use, has shown to make my enamel less clear, and has a normal toothpaste consistency and foams up great. I recommend it.
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Reviewed in the United States on March 20, 2024
★★★★★ 5
Great alternative to fluoride toothpaste.
Size: 4 Ounce (Pack of 4), Set name: Adult Mint
Taste great, does the job! Highly recommend!
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Reviewed in the United States on April 29, 2026
★★★★★ 3
No information on active ingredients.
Size: 4 Ounce (Pack of 4), Set name: Adult Mint
Gave 3 starts as an act of goodwill . The toothpaste does not specify the type or percentage of active ingredients it contains. For a beneficial effect, the concentration of nano-hydroxyapatite should be 10% or higher. Based on indirect information, this product appears to contain only about 4.2%.
The manufacturer did not respond to inquiries regarding the active ingredient content, which is concerning.
Additionally, the toothpaste has an unusual taste that is definitely not mint.
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Reviewed in the United States on April 21, 2026
★★★★★ 5
Great for Sensitive Teeth & Leaves My Mouth Feeling Clean
Size: Pack of 1, 4 Ounce, Set name: B. Whitening
Really impressed with the Boka Fluoride Free Toothpaste.
It has a clean, refreshing mint flavor without being overpowering, and it feels much gentler on sensitive teeth than other toothpastes I’ve tried.
My teeth feel smooth and clean after using it, and I like that the ingredients are simple and fluoride free. Definitely something I’ll keep repurchasing.
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Reviewed in the United States on May 25, 2026
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