SKU: 6360789387

FITC Human Anti-Human GM-CSF Antibody (S-2816)

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Description

FITC Human Anti-Human GM-CSF Antibody (S-2816)Product Specification Host Human Antigen GM CSF Synonyms Granulocyte macrophage colony stimulating factor; Colony stimulating factor (CSF); Molgramostin; Sargramostim; GMCSF; CSF2 Location Secreted Accession P04141 Clone Number S 2816 Antibody Type Recombinant mAb Application ICFCM Reactivity Hu Positive Sample Th1 Polarization Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1%

Product Specification


Host Human
Antigen GM-CSF
Synonyms Granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor (CSF); Molgramostin; Sargramostim; GMCSF; CSF2
Location Secreted
Accession P04141
Clone Number S-2816
Antibody Type Recombinant mAb
Application ICFCM
Reactivity Hu
Positive Sample Th1 Polarization Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
ICFCM 5μl per million cells in 100μl volume Hu

Background

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as CSF2, is a multifunctional glycoprotein cytokine that serves as a critical regulator of hematopoiesis and immune responses by binding to a specific heterodimeric receptor complex composed of an alpha chain (CD116) and a shared beta chain (CD131) on target cells. Primarily produced by activated macrophages, T cells, mast cells, endothelial cells, and fibroblasts in response to inflammatory stimuli, GM-CSF stimulates the proliferation, differentiation, survival, and functional activation of myeloid progenitor cells, driving their development into mature granulocytes (such as neutrophils, eosinophils, and basophils) and monocytes/macrophages while simultaneously enhancing the antimicrobial and antigen-presenting capabilities of these mature cells through mechanisms like increased phagocytosis, oxidative burst, and upregulation of MHC class II molecules. Beyond its physiological role in boosting host defense against infections and maintaining tissue homeostasis, GM-CSF plays a significant pathological role in chronic inflammatory and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where its overproduction contributes to sustained inflammation and tissue damage, making it a prominent therapeutic target for monoclonal antibodies aimed at blocking its signaling pathway, while recombinant forms of the protein (e.g., sargramostim) are clinically utilized to accelerate myeloid recovery following chemotherapy or bone marrow transplantation.

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SKU: 6360789387

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4.3 ★★★★★
Based on 11 reviews
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J
Verified Purchase
John Mix
Alexandria, US
★★★★★ 5
Love these socks!
The wife struggles with socks. She only like the Nike ones, then they discontinued them, so had to start the search again! Found these, they are expensive just like the Nike, but the size is true, they look great, they are super soft and stretchy. They are light weight and breathable and seem to wick away moisture. She loves these!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 18, 2025
G
Verified Purchase
Glass
Boise, US
★★★★★ 5
I stay on your foot they don’t slip in your shoe
Number of Items: 3, Color: White/Neutral (3-pairs), Size: Medium
This is the only socks I wear Under Armour because they stay in place I wear a size 8, but they’re more comfortable with a large instead of a medium, but I wear both because I have them already and you can pull them to stretch them out a little bit
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 12, 2026
L
Verified Purchase
Lauren
Battle Creek, US
★★★★★ 5
Great fit, truly doesn’t slide off heel
Number of Items: 3, Color: White/Neutral (3-pairs), Size: Medium, Number of Items: 3, Color: White/Neutral (3-pairs), Size: Medium
I’ve scoured all the lands looking for a no-show sock that was 1) thin, 2) quality, soft, breathable material, 3) didn’t dig into my feet/heels, 4) doesn’t shrink, and most importantly 5) stays on the back of my heel without a bulky non-slip rubber piece and these check all the boxes! Perfect for low profile women’s work shoes like Keds, etc. Not low enough for most flats though. I wear a women’s size 9.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 19, 2025
E
Verified Purchase
Elliz
Louisville, US
★★★★★ 5
So good - I’m buying MORE.
Number of Items: 3, Color: White (3-pairs), Size: Medium
I’m gonna give you more detail than you need about why I’m buying these socks again. I’ve been the mom of girl athletes. I’ve been a model and a fashion director. I’ve worn every brand of shoe on the planet and never found a shoe that did NOT find a vulnerable spot on my foot to rub raw. Even my beloved white Jack Purcell sneakers. With that said - I don’t like socks. I’ve bought a TON of them in 35+ years.....all major brands. They shift. They lose their shape. They get holes in them and wear out too fast. Not these. I retired this year, and knowing I’d be in sneakers a lot, traveling, sightseeing ...... I bought these 6 months ago and have worn them constantly. I’ve traveled with them. I’ve washed them in hot water and bleach. The socks are like brand new. They are exactly the right cut so as not to be seen in a basic sneaker. The little silicone patch on the heel stays put. Not once have I had to dig down into my shoe and pull the sock back up. The socks have stayed soft and EXACTLY the same as the day they were new. Like I said - I am back to buy them again. Great quality!
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Reviewed in the United States on January 20, 2021
J
Verified Purchase
Judy Fletcher
Waukegan, US
★★★★★ 5
No slip low socks
Number of Items: 3, Color: Black/White (3-pairs), Size: Medium
Perfect! ❤️ these!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 16, 2026

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