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Description
CD3 epsilon Recombinant Rabbit mAb (SDT-241-49)Product Specification Host Rabbit Antigen CD3 EPSILON Synonyms T cell surface antigen T3 Leu 4 epsilon chain, CD3e, T3E, CD3E Immunogen Synthetic Peptide Location Cell membrane Accession P07766 Clone Number SDT 241 49 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IP, IF Reactivity Hu, Ms, Rt Predicted Reactivity Rb, Mq, Pg, Sh Purification Protein A Concentration 0. 25 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%
Product Specification
| Host | Rabbit |
| Antigen | CD3 EPSILON |
| Synonyms | T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, T3E, CD3E |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P07766 |
| Clone Number | SDT-241-49 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IP, IF |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Rb, Mq, Pg, Sh |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500 | |
| IHC-P | 1:250-1:500 | |
| IP | 1:25 | |
| ICC | 1:250 | |
| IF | 1:1000 |
Background
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex. The CD3–T cell receptor (TCR) complex plays a central role in the T-cell-mediated immunoresponse as it is involved in the recognition of antigens and subsequent signal transduction and activation of immunocompetent T lymphocytes. Because CD3 is required for T cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for type 1 diabetes and other autoimmune diseases.
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