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Description
NPHS1 Recombinant Rabbit mAb (SDT-2148-63)Product Specification Host Rabbit Antigen NPHS1 Synonyms Nephrin; Renal glomerulus specific cell adhesion receptor; NPHN Immunogen Synthetic Peptide Location Cell membrane Accession O60500 Clone Number SDT 2148 63 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Human kidney, mouse kidney, rat kidney Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | NPHS1 |
| Synonyms | Nephrin; Renal glomerulus-specific cell adhesion receptor; NPHN |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | O60500 |
| Clone Number | SDT-2148-63 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human kidney, mouse kidney, rat kidney |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
NPHS1 protein, also known as nephrin, is a type-1 transmembrane protein primarily found in renal tissues, specifically at the slit diaphragm of glomerular podocytes. It is a member of the immunoglobulin family of cell adhesion molecules and plays a crucial role in the glomerular filtration barrier, functioning as an ultrafilter to exclude albumin and other plasma macromolecules from urine. Mutations in the NPHS1 gene can lead to Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
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