SKU: 65185124881

FITC Mouse Anti-Human CD146 Antibody (S-3679)

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Description

FITC Mouse Anti-Human CD146 Antibody (S-3679)Product Specification Host Mouse Antigen CD146 Synonyms Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma associated antigen A32; Melanoma associated antigen MUC18; S endo 1 endothelial associated antigen; MUC18; MCAM Location Membrane Accession P43121 Clone Number S 3679 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample HeLa Purification Protein G

Product Specification


Host Mouse
Antigen CD146
Synonyms Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; MUC18; MCAM
Location Membrane
Accession P43121
Clone Number S-3679
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample HeLa
Purification Protein G
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD146, also known as melanoma cell adhesion molecule (MCAM), is a 113-kDa, heavily glycosylated type-I transmembrane glycoprotein of the immunoglobulin superfamily that consists of five Ig-like domains (V-V-C2-C2-C2), a single transmembrane segment and a cytoplasmic tail existing in a long and a short splice isoform; initially identified on melanoma cells, it now is recognized as a multifunctional adhesion and signaling receptor widely expressed on endothelial cells, pericytes, smooth muscle, activated T cells and various stem cells that, through homophilic interactions and ligands such as laminin-411, Wnt5a and galectin-1, orchestrates angiogenesis, vascular integrity, cell migration, immune-cell trafficking and epithelial–mesenchymal transition, while its overexpression and elevated glycosylation in melanoma, renal, prostate, lung, pancreatic and other cancers correlate with tumor progression, metastasis and poor prognosis, and its soluble ectodomain (sCD146) released by metalloprotease shedding functions as a circulating biomarker, making CD146 a valuable diagnostic and therapeutic target in oncology and inflammatory diseases.

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SKU: 65185124881

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Quick and easy process with only reasonable verifications, no obfuscations or strange, ridiculous requirements.
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★★★★★ 1
Be careful this is not a true warranty
This is not a warranty. This is a refund of original price. I returned my sunglasses expecting to get replacements instead I got a gift card aboriginal purchase price and to my surprise the glasses have gone up like $70 in price not a very good warranty system.
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