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Description
Runx2 Recombinant Rabbit mAb (S-1767-173)Product Specification Host Rabbit Antigen Runx2 Synonyms Runt related transcription factor 2; Acute myeloid leukemia 3 protein; Core binding factor subunit alpha 1 (CBF alpha 1); Oncogene AML 3; Osteoblast specific transcription factor 2 (OSF 2); Polyomavirus enhancer binding protein 2 alpha A subunit (PEA2 alpha A; PEBP2 alpha A); AML3; CBFA1; OSF2; PEBP2A Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q13950 Clone Number S 1767
Product Specification
| Host | Rabbit |
| Antigen | Runx2 |
| Synonyms | Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1 (CBF-alpha-1); Oncogene AML-3; Osteoblast-specific transcription factor 2 (OSF-2); Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A; PEBP2-alpha A); AML3; CBFA1; OSF2; PEBP2A |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q13950 |
| Clone Number | S-1767-173 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Saos-2, PC-3, MDA-MB-231, C2C12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:500 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
Runx2, also known as Runt-related transcription factor 2, is a crucial transcription factor for bone development and plays a key role in the regulation of osteoblast differentiation and skeletal morphogenesis. It is expressed in prehypertrophic and hypertrophic chondrocytes, and its mutation can lead to skeletal malformation syndromes such as cleidocranial dysplasia. Runx2 induces chondrocyte maturation and proliferation through the regulation of various signaling pathways, including Indian hedgehog (Ihh) and vascular endothelial growth factor A (Vegfa). In addition to its role in normal bone development, Runx2 is also involved in pathological conditions such as breast cancer metastasis and lung fibrosis.
Shipping Notes
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Exchange/Return Notes
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