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Description
EHMT2/G9A Recombinant Rabbit mAb (S-4200)Product Specification Host Rabbit Antigen EHMT2 G9A Synonyms Histone lysine N methyltransferase EHMT2; Euchromatic histone lysine N methyltransferase 2; HLA B associated transcript 8; Histone H3 K9 methyltransferase 3 (H3 K9 HMTase 3); Lysine N methyltransferase 1C; Protein G9a; BAT8; C6orf30; KMT1C; NG36 Location Nucleus Accession Q96KQ7 Clone Number S 4200 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms,
Product Specification
| Host | Rabbit |
| Antigen | EHMT2/G9A |
| Synonyms | Histone-lysine N-methyltransferase EHMT2; Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3 (H3-K9-HMTase 3); Lysine N-methyltransferase 1C; Protein G9a; BAT8; C6orf30; KMT1C; NG36 |
| Location | Nucleus |
| Accession | Q96KQ7 |
| Clone Number | S-4200 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | MCF7, HL-60, HEK-293, HT-1080, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
| IF | 1:500 | Hu |
Background
EHMT2 (also called G9a) is a nuclear lysine methyltransferase that chiefly di-methylates histone H3 at lysine 9 (H3K9me2) and lysine 27 (H3K27me1/2) to establish facultative heterochromatin and transcriptionally silence target genes, and it can act either as a repressor or, through auto-methylation-dependent recruitment of cofactors such as HP1γ and p300, as a co-activator of transcription; the enzyme exists as a homodimer or heterodimer with the related GLP/EHMT1, contains an N-terminal ankyrin-repeat domain for chromatin docking and a catalytic SET domain for methyl transfer, and its dysregulation—via overexpression in diverse solid and hematologic cancers or down-regulation in addiction and neuropathic pain—alters the expression of hundreds of genes by both histone and non-histone methylation, thereby controlling embryonic development, stem-cell lineage commitment, immune-cell differentiation, synaptic remodeling, and tumorigenicity .
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