Pay in installments of $50.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Sep 1 - Sep 6
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotin Mouse Anti-Human FcεRIα Antibody (S-2866)Product Specification Host Mouse Antigen FcRI Synonyms High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc gamma RI (FcRI); Fc gamma RIA (FcgammaRIa); CD64; FCG1; FCGR1; IGFR1; FCGR1A Location Cell membrane Accession P12314 Clone Number S 2866 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid
Product Specification
| Host | Mouse |
| Antigen | FcεRIα |
| Synonyms | High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI (FcRI); Fc-gamma RIA (FcgammaRIa); CD64; FCG1; FCGR1; IGFR1; FCGR1A |
| Location | Cell membrane |
| Accession | P12314 |
| Clone Number | S-2866 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
FcεRIα is a single-pass transmembrane glycoprotein of the immunoglobulin superfamily that forms the ligand-binding backbone of the tetrameric high-affinity IgE receptor (FcεRI) expressed on mast cells and basophils; its extracellular region folds into two Ig-like domains that clamp the Fc portion of IgE with picomolar affinity, positioning the constant heavy-chain ε2-3 interface for optimal recognition, while a short cytoplasmic tail lacks signaling motifs but critically nucleates the entire receptor complex by juxtamembrane interactions with the four-helix FcεRIβ subunit and the disulfide-linked FcRγ homodimer, thereby dictating the architecture of the transmembrane three-helix bundle that propagates ITAM-based phosphorylation cascades upon IgE/allergen crosslinking and drives immediate degranulation, cytokine release and the clinical manifestations of type I hypersensitivity.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy