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Description
CD300LD Recombinant Rabbit mAb (S-1578-29)Product Specification Host Rabbit Antigen CD300LD Synonyms CMRF35 like molecule 5; CLM 5; CD300 antigen like family member D; CMRF35 A4; CD300d; CMRF35A4 Immunogen Synthetic Peptide Location Cell membrane Accession Q6UXZ3 Clone Number S 1578 29 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%
Product Specification
| Host | Rabbit |
| Antigen | CD300LD |
| Synonyms | CMRF35-like molecule 5; CLM-5; CD300 antigen-like family member D; CMRF35-A4; CD300d; CMRF35A4 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q6UXZ3 |
| Clone Number | S-1578-29 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
CD300LD is a member of the CD300 family of proteins and is a single transmembrane protein specifically highly expressed in neutrophils and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). It plays a significant role in tumor progression by regulating the recruitment of PMN-MDSCs and inhibiting T-cell infiltration through the STAT3-S100A8/A9 axis. Studies have shown that CD300LD knockout mice exhibit significantly inhibited tumor development, with reduced accumulation of PMN-MDSCs and increased numbers of immune effector cells such as CD4+ and CD8+ T cells and natural killer cells. This suggests that targeting CD300LD may remodel the tumor immune microenvironment from an immunosuppressive state to an activated state, offering potential for personalized targeted therapy. Additionally, CD300LD has been implicated in the regulation of interleukin-6 and tumor necrosis factor production, further highlighting its importance in immune responses.
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