SKU: 66835925679

Alexa Fluor® 700 Mouse Anti-Human CD33 Antibody (S-R472)

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Description

Alexa Fluor® 700 Mouse Anti-Human CD33 Antibody (S-R472)Product Specification Host Mouse Antigen CD33 Synonyms Myeloid cell surface antigen CD33; Sialic acid binding Ig like lectin 3 (Siglec 3); gp67; SIGLEC3 Location Cell membrane Accession P20138 Clone Number S R472 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 700 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin

Product Specification


Host Mouse
Antigen CD33
Synonyms Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3 (Siglec-3); gp67; SIGLEC3
Location Cell membrane
Accession P20138
Clone Number S-R472
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 700
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD33, also known as Siglec-3, is a 67 kDa type-I transmembrane sialic-acid-binding immunoglobulin-like lectin composed of an N-terminal V-set Ig domain that mediates glycan recognition, a membrane-proximal C2-set Ig domain, and a cytoplasmic tail harboring two immunoreceptor tyrosine-based inhibitory motifs (ITIMs); upon ligation by α2,3- or α2,6-linked sialylated glycoproteins or the complement component C1q, Src-family kinases phosphorylate these ITIMs, recruiting the SH2-domain-containing phosphatases SHP-1 and SHP-2 that dephosphorylate downstream signaling molecules, thereby suppressing calcium flux, PI3K activity, and activation of myeloid cells including monocytes, macrophages, dendritic cells, microglia, and myeloid-derived suppressor cells, while also modulating NK-cell cytotoxicity and cytokine production; CD33 is highly expressed on committed myeloid progenitors and over-expressed on >90 % of acute myeloid leukemias, making it the target of the antibody–drug conjugate gemtuzumab ozogamicin, and alternative splicing generates a shorter isoform lacking the ligand-binding V domain that can still dampen immune responses; genetically, the rs3865444(C) allele that reduces CD33 surface expression is protective against late-onset Alzheimer’s disease because lower microglial CD33 lessens inhibition of Aβ phagocytosis, implicating the receptor in neurodegeneration as well as in infection, autoimmunity, and cancer immune evasion.

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SKU: 66835925679

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Krystyn Florianovich
Louisville, US
★★★★★ 5
Lotion is more than I expected! It’s amazing!
LOVE this lotion! Already bought my 2nd bottle and about to order another one.
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Reviewed in the United States on March 27, 2026
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Hillary Paige
Alexandria, US
★★★★★ 1
Smells good
This product came destroyed the bottle was all busted up I still am using it but I had to move it to a different bottle because of the way that it came it smells good that's all I can really say about it
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Reviewed in the United States on April 23, 2026
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C Lewis
Pawtucket, US
★★★★★ 5
Would buy again
I love this stuff. It’s good value for money.
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Reviewed in the United States on March 17, 2026
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Amanda Clemens
Lowell, US
★★★★★ 5
Heaven in a bottle!
This stuff smells absolutely amazing! Soaks into the skin with no greasy aftermath & my tattoos love it! My new favorite lotion!
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Reviewed in the United States on July 18, 2025
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Alicia H.
Houston, US
★★★★★ 5
Smells great
Smells great and feels good on your skin
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Reviewed in the United States on September 5, 2025

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