SKU: 66993749813

Dulbecco's Modified Eagle's Medium (DMEM) - Modification 15

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Description

Dulbecco's Modified Eagle's Medium (DMEM) - Modification 15Dulbecco's Modified Eagle's Medium (DMEM) Modification 15 containing high glucose and L glutamine, but not containing sodium pyruvate or sodium bicarbonate, is a specialized formulation widely utilized in cell culture due to its tailored nutrient profile. This medium provides a high concentration of glucose, serving as a vital energy source, particularly beneficial for rapidly proliferating cells and those requiring high metabolic activity. The

Dulbecco's Modified Eagle's Medium (DMEM) - Modification 15 containing high glucose and L-glutamine, but not containing sodium pyruvate or sodium bicarbonate, is a specialized formulation widely utilized in cell culture due to its tailored nutrient profile. This medium provides a high concentration of glucose, serving as a vital energy source, particularly beneficial for rapidly proliferating cells and those requiring high metabolic activity. The inclusion of L-glutamine, an essential amino acid, supports protein synthesis and cellular metabolism, ensuring optimal growth and viability of cultured cells.

The absence of sodium pyruvate in this DMEM (Modification 15) is advantageous for specific experimental setups where the presence of pyruvate could interfere with metabolic studies or cellular processes under investigation. Similarly, the exclusion of sodium bicarbonate allows for precise pH control, especially in closed systems or during transport where CO2 levels cannot be regulated. This makes the medium highly adaptable for a variety of research conditions and applications.

Key applications of DMEM - Modification 15 include:

  • Metabolic Studies: Ideal for experiments focusing on cellular metabolism without the confounding effects of pyruvate.
  • Transport and Storage: Suitable for use in conditions where CO2 regulation is not feasible, maintaining stable pH levels.
  • Protein Expression: Supports high-density cell cultures for the production of recombinant proteins.
  • Cancer Research: Facilitates the growth of cancer cell lines that exhibit high metabolic rates.
  • Stem Cell Culture: Provides a nutrient-rich environment for the proliferation and differentiation of various stem cell types.

Disclaimer: Results may vary depending on specific cell lines, specifications, and experimental conditions. Consult with cell culture specialists and review comprehensive literature to tailor its use to your specific research needs.

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SKU: 66993749813

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4.4 ★★★★★
Based on 30 reviews
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Verified Purchase
Texas Filly
Lake Worth, US
★★★★★ 5
Great for heavy chewers, could be bigger.
Size: Large, Product Packaging: Standard Packaging
This tire is great.... if you have a small to medium dog. It's still very good for a large dog it's just harder to grab it when they have it in their mouth. It's great to throw in the yard, it rolls really well. My Am. Staffy/Bully loves it! For the price you can not go wrong! I'm sure this one (toy) will last quite a while!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 14, 2026
K
Verified Purchase
Kindle Customer
Fort Morgan, US
★★★★★ 4
Worth every penny.
Size: Large, Product Packaging: Standard Packaging
** Sept update.. the inner ring has taken a hit and started to unravel so we had to cut it off. The tire is still holding up! ** Bought this in Feb and it's still going strong. It's had a mal and dutch shep tugging on it and still held up. I am amazed and really like this one.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 15, 2025
C
Verified Purchase
Carly Englander
Lake Worth, US
★★★★★ 5
Fantastic dog toy
Size: Large, Product Packaging: Standard Packaging
Fantastic dog toy, probably my dogs favorite. It’s really durable, my dogs a heavy chewer and this toy has lasted several weeks. Will definitely buy again
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Reviewed in the United States on May 25, 2026
E
Verified Purchase
Eddie C.
Birmingham, US
★★★★★ 1
SAVE YOUR MONEY, THESE ARE UTTER GARBAGE UNLESS YOUR DOG HAS NO TEETH (MAYBE)!!
Size: Large, Product Packaging: Standard Packaging, Size: Large, Product Packaging: Standard Packaging
For all those purchasers who are posting videos of these toys while talking about how great they are and how long they have lasted at your house, would you mind disclosing the breed and age of your dog(s) that play with them? I only ask because I am finding these "positive" reviews REALLY hard to believe now that I have firsthand knowledge that, as a chew toy, this thing completely sucks. Based upon personal experience and the physical and photographic evidence, your dog might be an OBSESSIVE chewer, but they are most assuredly NOT a "power" chewer. If they were, you would almost certainly be posting reviews saying that this toy is utter crap, just like I'm having to do now. After many years of experience using Kong brand toys, the idea that this toy is the "most durable" Kong toy is just ridiculous, and blatant false advertising in my opinion. It took three of my dogs (a 5 year-old Boxer/Pit Bull mix (2nd pic) I'm fostering and two one year old border collie puppies) all of five minutes to completely shred FOUR of these toys straight out of the delivery box. I was the proud owner of four of these things for all of five frickin' minutes out of the box. Meanwhile, it previously took the Boxer/Pit almost two years to destroy two medium-sized Kong "snowman" shaped toys, and even then he wasn't able to shred them anywhere near to this degree. And believe me, he actually *IS* a true "power" chewer, as after raising and training dogs for over 50 years, I have never seen a dog completely break that type of Kong chew toy. As an aside, Kong (the company) appears to take crappy product claims only by means of printed hard copy sent via the U.S mail, so no immediate relief for your wasted expenditure on their products will soon be forthcoming. How many modern companies do you know of that don't allow some sort of online contact for product claims, even if it's just an email address? So I might very well have to reconsider whose products I am willing to spend my all-too hard earned money on. That said, those three dogs are all now outside throwing up chunks of these crappy toys that they swallowed while tearing them to pieces, and which I now find myself hoping really are non-toxic!! The regular "snowman" shaped Kong toys are MUCH more durable than these things are. Had I known that beforehand, I would have spent my money accordingly. The picture I posted is the last remaining toy out of the four I ordered, and I most certainly want my money back (wish me luck)!! This toy is a complete WASTE of your money for any dog that is bigger than an aged chihuahua or that actually has teeth, so I suggest that you DO NOT purchase.
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Reviewed in the United States on November 18, 2024
K
Verified Purchase
Kelly B. - Honest Hands-On
West Palm Beach, US
★★★★★ 5
Tough and Long-Lasting Toy for Heavy Chewers
Size: Large, Product Packaging: Standard Packaging
The KONG Extreme Tires are built for dogs who chew through just about everything else. Made from KONG’s most durable rubber, the toy is designed to stand up to strong jaws while also offering a fun shape that dogs enjoy rolling, chasing, and chewing. The tire design has grooves that can be stuffed with treats or peanut butter, which helps keep dogs engaged for longer play sessions. This toy is especially useful for large breeds or heavy chewers who usually destroy softer toys in minutes. While no toy is completely indestructible, the Extreme Tires hold up far better than most and provide both chewing satisfaction and mental stimulation. The size is hefty and best suited for medium to large dogs, and smaller breeds may find it too heavy. Pros: The rubber is extra durable, the tire shape adds variety and fun, and the grooves can be filled with treats for extra engagement. Cons: It may be too heavy for smaller dogs, strong chewers can still wear it down over time, and it isn’t designed to bounce or fly like other KONG toys. A rugged and reliable toy made for power chewers. The Extreme Tires provide long-lasting fun and double as a great option for treat-stuffing, making it one of KONG’s toughest and most useful toys.
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Reviewed in the United States on August 30, 2025

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