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Description
Invivo Anti-Mouse MHC Class I (H-2Kb) Recombinant mAbProduct Specification Host Mouse Antigen MHC Class I (H 2Kb) Synonyms H 2 class I histocompatibility antigen, K B alpha chain; H 2K(B); H2 K; H2 K1 Accession P01901 Antibody Type Mouse mAb Isotype Rat IgG2b,k Reactivity Ms Purification Protein A Concentration 5 mg ml Purity >95% by SEC HPLC Endotoxin <2EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer 2 to 8 C for 2 weeks under sterile conditions; 20 C for 3 months under sterile
Product Specification
| Host | Mouse |
| Antigen | MHC Class I (H-2Kb) |
| Synonyms | H-2 class I histocompatibility antigen, K-B alpha chain; H-2K(B); H2-K; H2-K1 |
| Accession | P01901 |
| Antibody Type | Mouse mAb |
| Isotype | Rat IgG2b,k |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Purity | >95% by SEC-HPLC |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | 2 to 8 °C for 2 weeks under sterile conditions; |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:500 | Ms |
Background
MHC Class I (H-2Kb) is a 45 kDa type I transmembrane glycoprotein encoded within the mouse MHC locus on chromosome 17, functioning as the murine ortholog of human HLA-A; it folds in the endoplasmic reticulum with a 12 kDa β2-microglobulin light chain to create a peptide-binding groove that preferentially accommodates 8–10-mer peptides bearing hydrophobic C-termini, and once loaded it is transported to the cell surface where it surveys CD8⁺ cytotoxic T lymphocytes for the presence of viral, tumor or self-peptides, thereby orchestrating rapid immune elimination of aberrant cells while maintaining tolerance through engagement of inhibitory receptors such as Ly49 and KIR.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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