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Description
Fc γ RIIA/CD32a His Tag Protein, Rhesus macaqueProduct Specification Species Rhesus macaque Synonyms Low affinity immunoglobulin gamma Fc region receptor II a, IgG Fc receptor II a, CDw32, Fc gamma RII a, Fc gamma RIIa, FcRII a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2 Accession H9BMP0 1 Amino Acid Sequence Gln34 Ile217, with C terminal His Expression System HEK293 Molecular Weight 31 35kDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His
Product Specification
| Species | Rhesus macaque |
| Synonyms | Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2 |
| Accession | H9BMP0-1 |
| Amino Acid Sequence | Gln34-Ile217, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 31-35kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16) can produce multiple subtypes. There are 3 Fc γ RII / CD32 genes (A, B and C) in human, 2 genes in monkeys (A and B) and one Fc γ RII B in mice. Mature Fc γ RIIA is a type 1 transmembrane glycoprotein. About 40 kDa is composed of extracellular domain, transmembrane domain and cytoplasmic domain, and the extracellular domain includes two IgG domains. Monkey Fc γ RIIA protein has 89% homology with human Fc γ RIIA. CD32a is expressed in a variety of immune cells, such as macrophages, neutrophils, platelets, etc., and initiates inflammatory responses during ligand binding, including cytolysis, phagocytosis, degranulation and production of cytokines. This response can be regulated by co-expression of inhibitory receptors such as CD32B, and the intensity of the signal depends on the proportion of activated and inhibitory receptors.
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