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Description
Alexa Fluor® 488 Rat Anti-Mouse CD5 Antibody (S-R732)Product Specification Host Rat Antigen CD5 Synonyms T cell surface glycoprotein CD5; Lymphocyte antigen 1 (Ly 1; Lyt 1); Ly 1; Cd5 Location Cell membrane Accession P13379 Clone Number S R732 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Rat |
| Antigen | CD5 |
| Synonyms | T-cell surface glycoprotein CD5; Lymphocyte antigen 1 (Ly-1; Lyt-1); Ly-1; Cd5 |
| Location | Cell membrane |
| Accession | P13379 |
| Clone Number | S-R732 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD5, also known as T-cell surface glycoprotein CD5 or Leu-1, is a type I transmembrane glycoprotein expressed on the surface of T cells, thymocytes, and a subset of B cells called B-1a cells. It belongs to the scavenger receptor superfamily and has a molecular mass of approximately 67 kDa. CD5 plays a crucial role in modulating immune responses by regulating the activation of T cells and B cells. In T cells, CD5 expression is upregulated upon activation and helps to fine-tune T cell receptor (TCR) signaling, promoting cell survival and non-responsiveness. In B cells, particularly B-1a cells, CD5 helps to prevent overactivation by dampening signals from the B cell receptor (BCR), ensuring that these cells only respond to strong stimuli. The exact ligand for CD5 remains unclear, but it is suggested that it may interact homophilically or with CD72 on B cells.
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