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Description
CCL15/MIP-1δ/LKN-1(68aa) Protein, HumanProduct Specification Species Human Synonyms C C motif chemokine 15; Chemokine CC 2 (HCC 2); Leukotactin 1 (LKN 1); MIP 1 delta; Macrophage inflammatory protein 5 (MIP 5); Mrp 2b; NCC 3; Small inducible cytokine A15; Accession Q16663 Amino Acid Sequence Ser46 Ile113 Expression System E. coli Molecular Weight 7. 4 kDa (Reducing) Purity >95% by SDS PAGE. Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris,
Product Specification
| Species | Human |
| Synonyms | C-C motif chemokine 15; Chemokine CC-2 (HCC-2); Leukotactin-1 (LKN-1); MIP-1 delta; Macrophage inflammatory protein 5 (MIP-5); Mrp-2b; NCC-3; Small-inducible cytokine A15; |
| Accession | Q16663 |
| Amino Acid Sequence | Ser46-Ile113 |
| Expression System | E.coli |
| Molecular Weight | 7.4 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 300mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | BMC Genomics . 2008 May 15:9:222. |
Background
MIP-1δ, a member of the CC chemokine family, is known for its role in regulating immune responses and inflammation. It functions as a chemoattractant for various immune cells, including monocytes, dendritic cells, and lymphocytes, by binding to its cognate receptor, CCR1. This interaction leads to the recruitment of immune cells to sites of inflammation or infection.
In addition to its chemotactic properties, MIP-1δ has been implicated in modulating immune cell activation and differentiation. It can influence the polarization of T cells towards specific effector phenotypes, such as Th1 or Th2 cells, by regulating the expression of cytokines and chemokines. MIP-1δ is also involved in the regulation of inflammatory responses and has been linked to the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
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