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Description
Fc γ RIIA/CD32a His Tag Protein, RatProduct Specification Species Rat Synonyms Low affinity immunoglobulin gamma Fc region receptor II a, IgG Fc receptor II a, CDw32, Fc gamma RII a, Fc gamma RIIa, FcRII a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2 Amino Acid Sequence Gln34 Leu216, with C terminal His Expression System HEK293 Molecular Weight 34 53 kDa(reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 2EU g Conjugation Unconjugated Tag His Tag Physical Appearance
Product Specification
| Species | Rat |
| Synonyms | Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2 |
| Amino Acid Sequence | Gln34-Leu216, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 34-53 kDa(reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.2EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16) can produce multiple subtypes. CD32 is a low affinity receptor of IgG. There are 3 Fc γ RII / CD32 genes (A, B and C) in human, 2 genes in monkeys (An and B) and one Fc γ RII B in mice. Mature Fc γ RIIA is a type 1 transmembrane glycoprotein. About 40 kDa is composed of extracellular domain, transmembrane domain and cytoplasmic domain, and the extracellular domain includes two IgG domains. The extracellular domain Fc γ RIIA of rat shares 52% of the amino acid sequence with that of human Fc γ RIIA. CD32a is expressed in a variety of immune cells, such as macrophages, neutrophils, platelets and so on. Inhibition of ITIM receptors may also be co-expressed and co-participated by specific ligands to initiate inflammatory responses during ligand binding, including cytolysis, phagocytosis, degranulation and production of cytokines. This response can be regulated by co-expression of inhibitory receptors such as CD32B, and the intensity of the signal depends on the proportion of activated and inhibitory receptors.
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