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Description
PKM Recombinant Rabbit mAb (S-812-20)Product Specification Host Rabbit Synonyms Pyruvate kinase PKM, Cytosolic thyroid hormone binding protein (CTHBP), Opa interacting protein 3(OIP 3), Pyruvate kinase 2 3, Pyruvate kinase muscle isozyme, Threonine protein kinase PKM2, Thyroid hormone binding protein 1 (THBP1), Tumor M2 PK, Tyrosine protein kinase PKM2, p58, OIP3 , PK2, PK3, PKM2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P14618 Clone Number S 812 20 Antibody Type
Product Specification
| Host | Rabbit |
| Synonyms | Pyruvate kinase PKM, Cytosolic thyroid hormone-binding protein (CTHBP), Opa-interacting protein 3(OIP-3), Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Threonine-protein kinase PKM2, Thyroid hormone-binding protein 1 (THBP1), Tumor M2-PK, Tyrosine-protein kinase PKM2, p58, OIP3 , PK2, PK3, PKM2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P14618 |
| Clone Number | S-812-20 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or, Ct, Rb |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| IHC-P | 1:500 | |
| ICC | 1:500 | |
| ICFCM | 1:500 |
Background
Pyruvate kinase is the enzyme involved in the last step of glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to adenosine diphosphate (ADP), yielding one molecule of pyruvate and one molecule of ATP. In contrast to mitochondrial respiration, energy regeneration by pyruvate kinase is independent from oxygen supply and allows survival of the organs under hypoxic conditions often found in solid tumors. Pyruvate kinase is present in four distinct, tissue-specific isozymes in animals, each consisting of particular kinetic properties necessary to accommodate the variations in metabolic requirements of diverse tissues.
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