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Description
TrkC Fc Chimera Protein, HumanProduct Specification Species Human Synonyms TrkC, Ntrk3 Accession Q96CY4 Amino Acid Sequence Cys32 Asp428, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | TrkC, Ntrk3 |
| Accession | Q96CY4 |
| Amino Acid Sequence | Cys32-Asp428, with C-terminal Human IgG1 Fc CPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 95-115kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Khotskaya Y B. et al. (2017). Targeting TRK family proteins in cancer. Review. 173:58-66. |
Background
The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins, which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of neurotrophins to TRK proteins induces receptor dimerization, phosphorylation, and activation of the downstream signaling cascades via PI3K, RAS/MAPK/ERK, and PLC-gamma. TrkC functions not only as an oncogene, but also act as a tumor suppressor via a manner of dependence receptor in human malignant tumors. TrkC is a potent oncoprotein expressed in tumors derived from multiple cell lineages, and functions as an active protein tyrosine kinase by neurotrophin-3 (NT-3).
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4.9 ★★★★★
Based on 27 reviews
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Product Reviews
★★★★★ 4
Reversable .worth the money
Color: Lavender, Size: Twin XL
Color was a bit disappointing. But the white side is fluffy and beautiful. Washes great and perfectly fluffed dry.
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Reviewed in the United States on February 28, 2026
★★★★★ 5
Comfy and warm
Color: Charcoal, Size: Full/Queen
Very warm and comfy.
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Reviewed in the United States on April 23, 2026
★★★★★ 5
what you see is what you get
Color: Smoke Blue, Size: King
It is so soft & cuddly.....It washes well,& the color is as you see in photo,
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Reviewed in the United States on March 5, 2026
★★★★★ 5
Perfect Sherpa Comforter
Color: Lavender, Size: Full/Queen
Love this comforter!! Perfect material and weight for cold winter nights, beautiful color! Just wish I had found it and ordered it sooner!
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Reviewed in the United States on February 8, 2026
★★★★★ 5
In love
Color: Smoke Blue, Size: Full/Queen, Color: Smoke Blue, Size: Full/Queen
I am very weird with needing a certain kind of texture on me while I sleep, to provide me with a warmth and at ease sleep. It's super soft on both sides. Providing a certain level of coziness. I absolutely love the way this color looks- in person and on line. Overall, I love love it. The price is very reasonable. The color i chose creates a great ombiance for what i'm looking for in my room. They have so many colors to choose from. I def would give this a try. How could you not. Especially with free shipping and returns. Its a win win. I will be buying more colors in the future. Anyone who love the feel of uggs blankets. Will probably love this. The material isn't the same of course (but) it certainly works. I have an ugg throw on my bed as well and I like both. This blanket feels lighter compared to the ugg throw blanket (but) it has the same sorta softness in the inside. The ugg throw is much thicker than this blanket. Obviously, it's hard to compare the two. Hope this helps
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Reviewed in the United States on June 14, 2023