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Description
CDK2 Recombinant Rabbit mAb (SDT-064-40)Product Specification Host Rabbit Antigen CDK2 Synonyms Cyclin dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDKN2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Endosome Accession P24941 Clone Number SDT 064 40 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IP, ICFCM Reactivity Hu, Ms, Rt Predicted Reactivity Hm, Bv Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | CDK2 |
| Synonyms | Cyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDKN2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Endosome |
| Accession | P24941 |
| Clone Number | SDT-064-40 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IP, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Hm, Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:5000 | |
| IHC-P | 1:500 | |
| ICFCM | 1:500 | |
| IP | 1:25 | |
| ICC | 1:500 |
Background
Cyclin-dependent kinases (CDKs) are essential kinases that drive cell cycle transformation and transcriptional regulation [PMID: 30185601, PMID: 30375919]. CDKs involve in a variety of biological processes, including cell metabolism, differentiation, and development. Human CDKs are mainly divided into two categories: 1) One group is involved in cell cycle regulation and related to mitosis, and the subtypes are CDK1, 2, 3, 4, and 6. 2) Another group is mainly involved in transcriptional regulation, regulating phosphorylation of RNA polymerase II, and the subtypes are CDK7, 8, 9, and 11 [PMID: 19561645].CDK2 plays a key role in cell cycle regulation [PMID: 14657662, PMID: 30543440, PMID: 30516105]. CDK2 forms a complex with Cyclin E and then phosphorylates Rb, therefore activates E2F [PMID: 24876129]. CDK2-Cyclin A complex promotes cells to pass through the S/G2 checkpoint. CDK2 also controls the phosphorylation of many transcription factors including Smad3 [PMID: 16289004], FoxM1, FoxO1 [PMID: 11250068], NFY, B-Myb [PMID: 14625684], Myc [PMID: 20445224] and promotes the cell cycle. In addition, CDK2 also plays an important role in DNA replication [PMID: 34901021], adaptive immune response, cell differentiation, and apoptosis [PMID: 15617830, PMID: 19561645].
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