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Description
PMEL/Melanoma gp100 Recombinant Rabbit mAb ,PBS Only(SDT-3393)Product Specification Host Rabbit Antigen PMEL Melanoma gp100 Synonyms Melanocyte protein PMEL; ME20 M (ME20M); Melanocyte protein Pmel 17; Melanocytes lineage specific antigen GP100; Melanoma associated ME20 antigen; P1; D12S53E; PMEL17; SILV; PMEL Location Endosome, Melanosome, Endoplasmic reticulum membrane Accession P40967 Clone Number SDT 3393 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | PMEL/Melanoma gp100 |
| Synonyms | Melanocyte protein PMEL; ME20-M (ME20M); Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; D12S53E; PMEL17; SILV; PMEL |
| Location | Endosome, Melanosome, Endoplasmic reticulum membrane |
| Accession | P40967 |
| Clone Number | SDT-3393 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | SK-MEL-28, B16-F0 |
| Purification | Protein A |
| Concentration | 1mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
PMEL (premelanosome protein), also called melanoma gp100, is a ~100 kDa type-I transmembrane glycoprotein encoded by the PMEL gene; it is expressed almost exclusively in pigment cells, where it is trafficked to the melanosome lumen, proteolytically processed by furin-like convertases and BACE2, and then self-assembles into non-pathological amyloid fibrils that form the striated matrix on which melanin is deposited, while concurrently its peptide fragments—particularly the gp100280–288 epitope—are presented on HLA-A*02:01 and recognized by cytotoxic T lymphocytes, making PMEL/gp100 a pivotal structural component of melanosome biogenesis and one of the most important melanoma-associated antigens targeted by immunotherapies such as tebentafusp.
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