SKU: 69905776733

Biotin Mouse Anti-Human CD33 Antibody (S-R472)

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Description

Biotin Mouse Anti-Human CD33 Antibody (S-R472)Product Specification Host Mouse Antigen CD33 Synonyms Myeloid cell surface antigen CD33; Sialic acid binding Ig like lectin 3 (Siglec 3); gp67; SIGLEC3 Location Cell membrane Accession P20138 Clone Number S R472 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300

Product Specification


Host Mouse
Antigen CD33
Synonyms Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3 (Siglec-3); gp67; SIGLEC3
Location Cell membrane
Accession P20138
Clone Number S-R472
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD33, also known as Siglec-3, is a 67 kDa type-I transmembrane sialic-acid-binding immunoglobulin-like lectin composed of an N-terminal V-set Ig domain that mediates glycan recognition, a membrane-proximal C2-set Ig domain, and a cytoplasmic tail harboring two immunoreceptor tyrosine-based inhibitory motifs (ITIMs); upon ligation by α2,3- or α2,6-linked sialylated glycoproteins or the complement component C1q, Src-family kinases phosphorylate these ITIMs, recruiting the SH2-domain-containing phosphatases SHP-1 and SHP-2 that dephosphorylate downstream signaling molecules, thereby suppressing calcium flux, PI3K activity, and activation of myeloid cells including monocytes, macrophages, dendritic cells, microglia, and myeloid-derived suppressor cells, while also modulating NK-cell cytotoxicity and cytokine production; CD33 is highly expressed on committed myeloid progenitors and over-expressed on >90 % of acute myeloid leukemias, making it the target of the antibody–drug conjugate gemtuzumab ozogamicin, and alternative splicing generates a shorter isoform lacking the ligand-binding V domain that can still dampen immune responses; genetically, the rs3865444(C) allele that reduces CD33 surface expression is protective against late-onset Alzheimer’s disease because lower microglial CD33 lessens inhibition of Aβ phagocytosis, implicating the receptor in neurodegeneration as well as in infection, autoimmunity, and cancer immune evasion.

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SKU: 69905776733

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4.5 ★★★★★
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Elyse
Boise, US
★★★★★ 5
The CUTEST omg
Size: 13 Big Kid, Color: Glitter Pink, Size: 13 Big Kid, Color: Glitter Pink
These pink glitter platform sandals are the ultimate 'cool girl' shoe for toddlers. The sparkle is embedded in the material so it doesn't shed, and the platform is stable enough for confident walking. Insight: Like all Melissa’s, they have that heavenly bubblegum scent that lasts for months. These are the most comfortable shoes ever! They feel like walking on a cloud, I have several pairs myself and they are the BEST. Strap is durable and comfy. They are surprisingly lightweight for a platform sandal! These shoes run big and do not do half sizes so if between sizes size down for a perfect fit
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 3, 2026
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Jhem Pascua
Whiting, US
★★★★★ 5
Perfect
Size: 9 Toddler, Color: Pink/Glitter, Size: 9 Toddler, Color: Pink/Glitter
My daughter loves it. I read all the reviews they all complain it’s runs small and yes it’s runs small. My daughter she’s a size 6 and i ordered size 9, and it perfect fit to my daughter.
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Reviewed in the United States on February 6, 2026
A
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Amanda
Boise, US
★★★★★ 5
Adorable
Size: 8 Toddler, Color: Brown/White
This particular one I had to upsize. I didn’t return because I have another little girl that was going to use them. Typically all mini Melissa’s are true to size. Loved them. Super cute.
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Reviewed in the United States on March 6, 2026
M
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mzb
Charlottesville, US
★★★★★ 5
Cutest sandals for your little one (as long as they aren't learning to walk)
Size: 6 Toddler, Color: Brown/White
The sandals are adorable and great quality. However, when I showed the pediatrician before putting them on our 14 month old who is walking everywhere. She said "do not use" for children who are just learning to walk...these are great for those that aren't a "toddler" yet.
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Reviewed in the United States on May 26, 2025
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ToshyLou
Omaha, US
★★★★★ 4
Size up for sure!
Size: 9 Toddler, Color: Matt Black
Bought these as a gift for my niece who wears a size 8 in toddlers. There is a note to size up from the seller but you may need to size up 3x. Ordered a 9 in the cozy jelly sandals, one size up as suggested & they were way too small. So I tried them on my other niece who is wearing a size 6 in toddlers & the 9 fit her perfect. She loved them & walked comfortably, she didn’t stomp as she usually does if the shoes are too heave or firm. & they have a nice sweet smell. I like that the Velcro straps adjust to fit her snug enough to hold her skinny foot in place. Definitely like the look, feel & quality. The sizing is really difficult to get right, I imaging depending on the style this may also differ.
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Reviewed in the United States on December 4, 2025

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