SKU: 70186842798

HVEM/TNFRSF14 His Tag Protein, Human

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Description

HVEM/TNFRSF14 His Tag Protein, HumanProduct Specification Species Human Synonyms TNFRSF14,ATAR, HVEA, LIGHTR, TR2, CD270 Accession Q92956 1 Amino Acid Sequence Leu39 Val202, with C terminal His Expression System HEK293 Molecular Weight 30 43kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms TNFRSF14,ATAR, HVEA, LIGHTR, TR2, CD270
Accession Q92956-1
Amino Acid Sequence Leu39-Val202, with C-terminal His
Expression System HEK293
Molecular Weight

30-43kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Steinberg MW, et al. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 205(6): 1463-76. 

2.Pasero C, et al. (2009) A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. Eur J Immunol. 39(9): 2502-14.

Background

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily.It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

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SKU: 70186842798

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Ken R
Los Angeles, US
★★★★★ 5
Great shirt! Comfortable
Size: 16.5" Neck 32"-33" Sleeve, Color: Granite
Great shirt! Just as advertised! Bought 3 more
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Reviewed in the United States on January 28, 2026
M
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Marie1
Cuba, US
★★★★★ 5
Good value.
Size: 18.5" Neck 36"-37" Sleeve, Color: Blue
This shirt is good looking and great fit. Color is great. Easy to care for.
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Reviewed in the United States on December 5, 2025
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John G.
Cuba, US
★★★★★ 5
Better than I thought, although I love the brand
Size: 15" Neck 32"-33" Sleeve, Color: Midnight, Size: 15" Neck 32"-33" Sleeve, Color: Midnight
Super nice quality shirt really good price
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Reviewed in the United States on January 11, 2026
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Art Vandelay
Pawtucket, US
★★★★★ 5
Good Fit for a Bigger Guy
Size: 18" Neck 34"-35" Sleeve, Color: Vert
I'm a bigger guy--6-foot, 240lbs--so I struggle sometimes with finding the right fit. This shirt fit my broad shoulders and ample mid-section with ease, and I was even able to tuck it in. I have long arms (76-inch reach), and this shirt fit the bill. I liked this shirt so much that I ordered seven colors--enough for each day of the week. After a year, the fabric is still strong and the colors vibrant.
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Reviewed in the United States on January 3, 2025
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Harley Boyd
Cuba, US
★★★★★ 3
Some wrinkles
Size: 17.5" Neck 36"-37" Sleeve, Color: Vert
I would say that it’s more wrinkle resistant than wrinkle free, you’ll probably still have to iron this one. The collar stays are sewn inside the shirt collar so they cannot be changed or replaced (not compatible with magnetic collar stays). Otherwise it fits well and was reasonably priced but not quite what I wanted.
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Reviewed in the United States on February 18, 2025

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