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Description
FITC Armenian hamster Anti-Human/Mouse/Rat CD278 Antibody (S-R578)Product Specification Host Armenian hamster Antigen CD278 Synonyms Inducible T cell costimulatory; Activation inducible lymphocyte immunomediatory molecule; ICOS; AILIM Location Cell membrane Accession Q9Y6W8 Clone Number S R578 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Hu, Ms, Rt Purification Protein G Concentration 0. 05mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3%
Product Specification
| Host | Armenian hamster |
| Antigen | CD278 |
| Synonyms | Inducible T-cell costimulatory; Activation-inducible lymphocyte immunomediatory molecule; ICOS; AILIM |
| Location | Cell membrane |
| Accession | Q9Y6W8 |
| Clone Number | S-R578 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD278, also known as ICOS (inducible T-cell co-stimulator), is a member of the CD28 superfamily and is expressed on activated T cells, including regulatory T cells (Tregs) and follicular helper T cells (Tfh). It functions as a homodimer and plays a crucial role in T cell activation, proliferation, and differentiation. ICOS binds to its ligand ICOSL (CD275), which is expressed on antigen-presenting cells (APCs) such as dendritic cells, B cells, and macrophages. This interaction enhances T cell-mediated immune responses, promotes cytokine production (e.g., IL-4, IL-13), and supports the survival and function of Tfh cells, which are critical for B cell antibody production. ICOS signaling is also involved in Th2 and Th17 cell differentiation and has been implicated in autoimmune and inflammatory diseases. In cancer immunotherapy, ICOS agonist antibodies have shown potential for enhancing anti-tumor immune responses when combined with other immunotherapies.
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