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Description
CD352/SLAM6 Recombinant Rabbit mAb (SDT-2472-77)Product Specification Host Rabbit Antigen CD352 SLAM6 Synonyms SLAM family member 6; Activating NK receptor; NK T B antigen (NTB A); KALI Immunogen Recombinant Protein Location Cell membrane Accession Q96DU3 Clone Number SDT 2472 77 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu Positive Sample Ramos, Jurkat, Daudi, Raji Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CD352/SLAM6 |
| Synonyms | SLAM family member 6; Activating NK receptor; NK-T-B-antigen (NTB-A); KALI |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q96DU3 |
| Clone Number | SDT-2472-77 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu |
| Positive Sample | Ramos, Jurkat, Daudi, Raji |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
| IHC-P | 1:200 | Hu |
| IF | 1:200 | Hu |
Background
CD352 (also known as SLAMF6, NTB-A, or LY108) is a type I transmembrane glycoprotein belonging to the signaling lymphocytic activation molecule (SLAM) family and a member of the CD2 subfamily of immunoregulatory receptors. This protein is expressed on the surface of natural killer (NK) cells, T cells (upregulated upon activation), and B cells, functioning through homophilic interactions to regulate NK cell cytotoxicity, T cell co-stimulation (independent of CD28), Th1 cytokine production, and B cell tolerance. The extracellular domain of CD352 contains Ig-like domains, while its intracellular region harbors conserved tyrosine-based signaling motifs that can be phosphorylated and recruit adaptor proteins such as SH2D1A (SAP) and SH2D1B (EAT-2), thereby modulating innate and adaptive immune responses. Studies indicate that reduced CD352 expression in multiple myeloma (MM) may be linked to its role in immune regulation and the tumor microenvironment. Additionally, CD352 activation promotes T cell proliferation and cytokine secretion while triggering cytolytic activity and signal transduction cascades in NK cells.
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