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Description
Human ALPL Protein, His TagProduct Specification Species Human Synonyms Alkaline phosphatase, tissue nonspecific isozyme, AP TNAP, TNAP, TNSALP, Alkaline phosphatase 2, Alkaline phosphatase liver bone kidney isozyme, Phosphoamidase, Phosphocreatine phosphatase, Akp 2, Akp2 Accession P09242 Amino Acid Sequence Protein sequence (P09242, Phe18 Ser502, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNAP, TNSALP, Alkaline phosphatase 2, Alkaline phosphatase liver/bone/kidney isozyme, Phosphoamidase, Phosphocreatine phosphatase, Akp-2, Akp2 |
| Accession | P09242 |
| Amino Acid Sequence | Protein sequence (P09242, Phe18-Ser502, with C-His Tag) FVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNLKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWAGS |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 55.3 kDa Observed MW: 65-90 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Alkaline Phosphatase, Tissue-Nonspecific Isozyme (TNAP) is a ubiquitously expressed enzyme encoded by the ALPL gene. As the predominant alkaline phosphatase in humans, it is crucial for bone and tooth mineralization. TNAP hydrolyzes inorganic pyrophosphate, a potent mineralization inhibitor, and provides inorganic phosphate to promote hydroxyapatite crystal growth. Beyond its skeletal role, TNAP is also vital in neuronal development, vitamin B6 metabolism, and modulating intestinal inflammation. Mutations in ALPL cause hypophosphatasia, a metabolic bone disorder characterized by defective mineralization. Thus, TNAP serves as a central regulator of phosphate metabolism across multiple physiological systems.
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