Pay in installments of $27.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 30 - Sep 4
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Human IgA1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Human IgA1 Synonyms Immunoglobulin heavy constant alpha 1; Ig alpha 1 chain C region; Ig alpha 1 chain C region BUR; Ig alpha 1 chain C region TRO; IGHA1 Immunogen Synthetic Peptide Location Secreted, Cell membrane Accession P01876 1 Antibody Type Polyclonal antibody Isotype IgG Application IHC P Reactivity Hu Purification Immunogen Affinity Concentration 0,5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | Human IgA1 |
| Synonyms | Immunoglobulin heavy constant alpha 1; Ig alpha-1 chain C region; Ig alpha-1 chain C region BUR; Ig alpha-1 chain C region TRO; IGHA1 |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Cell membrane |
| Accession | P01876-1 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Immunogen Affinity |
| Concentration | 0,5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000-1:2000 | Hu |
Background
Human IgA1 (Immunoglobulin A1) is a type of antibody that plays a crucial role in the immune system. It is the most abundant immunoglobulin found in mucosal secretions such as saliva, tears, and gastrointestinal fluids, where it helps to prevent infections by neutralizing pathogens and preventing their attachment to mucosal surfaces. Structurally, IgA1 consists of two heavy chains and two light chains, with a unique hinge region that makes it more susceptible to proteolytic cleavage compared to other immunoglobulins. This protein is synthesized by plasma cells and is often found in both monomeric and dimeric forms, with the dimeric form being particularly important in mucosal immunity due to its higher avidity. Abnormalities in IgA1, such as glycosylation defects, have been implicated in certain autoimmune and inflammatory diseases, including IgA nephropathy.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy