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Description
SLAMF7/CRACC/CD319 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms SLAMF7, CD319, CS1, CRACC, 19A, FOAP 12 Accession XP_005541294. 2 Amino Acid Sequence Ser23 Met226, with C terminal 10*His SGSVKELVGSIGGAVTFPLKSEVKQVDSIVWTFNTTTLVTIQPEGGPMIVTQNRNKERVDFPDGGYSLKLSKLKKNDSGIYNVEIYSSSLQDPFTRKYVLRVYEHLSKPKVTMGLQSNKNGTCVTNLTCHMEHGEEDVIYTWKALGQAVNESHNGSILPISWRWGESDMTFICTVRNPVSSNSSSPILARKLCEGAADDSDSSMGGGSGGGSHHHHHHHHHH Expression System HEK293 Molecular Weight 35 45kDa Purity
Product Specification
| Species | Cynomolgus |
| Synonyms | SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12 |
| Accession | XP_005541294.2 |
| Amino Acid Sequence | Ser23-Met226, with C-terminal 10*His SGSVKELVGSIGGAVTFPLKSEVKQVDSIVWTFNTTTLVTIQPEGGPMIVTQNRNKERVDFPDGGYSLKLSKLKKNDSGIYNVEIYSSSLQDPFTRKYVLRVYEHLSKPKVTMGLQSNKNGTCVTNLTCHMEHGEEDVIYTWKALGQAVNESHNGSILPISWRWGESDMTFICTVRNPVSSNSSSPILARKLCEGAADDSDSSMGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Lee J K. et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-2799. 2、Tassi I. et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002. 3、Lee J K. et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-4678. 4、Cruz-Munoz M E. et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305. |
Background
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. Mature mouse CRACC consists of a 202 amino acid (aa) extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain, a 21 aa transmembrane segment, and an 88 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function.
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4.2 ★★★★★
Based on 15 reviews
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Product Reviews
★★★★★ 5
Great shirt!
Size: X-Large, Color: Purple Buffalo
Love it! Light, stretchy, and breathable! The shirt itself is so nice to wear, I’ll probably buy other patterns!
I bought a dozen of these in different sizes for a golf tournament. Sizes ran true. Nice athletic fit!
This pattern made us just the right amount of obnoxious out on the course! Great vibrant violet color from afar, cool pattern up close!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 23, 2026
★★★★★ 5
Shoe
Size: 10-11 Women/9-10 Men, Color: 1a-stripe Black-2
These beach shoes have been super comfortable and practical. They fit well, are lightweight, and the sole has great grip, even on wet surfaces. I used them at the beach and by the pool, and they protected my feet really well from hot sand and rocks. They also dry quickly and are easy to carry.
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Reviewed in the United States on May 14, 2026
★★★★★ 5
Good, quick, easy water shoes.
Size: 8-9 Women/7-8 Men, Color: 1a-stripe Black-2
For the price? Great little water shoes for a small body of water! Size is accurate, material is breathable, the shoes are lightweight and no cuts/scrapes when out of the water noted. Good buy!
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Reviewed in the United States on June 1, 2026
★★★★★ 5
Comfortable to Wear
Size: 11.5-12.5 Women/10.5-11.5 Men, Color: 2c-1172 Watermarks
These are easy to put on and extremely comfortable. The material seems thicker than my old water shoes, so should last longer. The soles provide good grip, even in a swimming pool, which makes them ideal for use in activities like water aerobics. The color flashes on the shoes make them interesting and more appealing than plain black. Highly recommended
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Reviewed in the United States on May 24, 2026
★★★★★ 4
Comfy Pool Shoes
Size: 11.5-12.5 Women/10.5-11.5 Men, Color: 1a-stripe Black-2
I’ve had these pool shoes a couple of months now. Here are my thoughts.
Pros: Inexpensive, comfortable, fit well, dry fast, protect feet for you pool joggers.
Cons: The inner sole gets loose, the material around the toes breaks down.
Bottom line: For the money they’re worth it. Just don’t expect them to last a long time.
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Reviewed in the United States on February 4, 2026
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