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Description
Uteroglobin Recombinant Rabbit mAb (SDT-2736-46)Product Specification Host Rabbit Antigen Uteroglobin Synonyms Club cell phospholipid binding protein (CCPBP); Club cells 10 kDa secretory protein (CC10); Secretoglobin family 1A member 1; Urinary protein 1 (UP 1; UP1; Urine protein 1); CC10; CCSP; UGB; SCGB1A1 Immunogen Recombinant Protein Location Secreted Accession P11684 Clone Number SDT 2736 46 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu Positive Sample BxPC
Product Specification
| Host | Rabbit |
| Antigen | Uteroglobin |
| Synonyms | Club cell phospholipid-binding protein (CCPBP); Club cells 10 kDa secretory protein (CC10); Secretoglobin family 1A member 1; Urinary protein 1 (UP-1; UP1; Urine protein 1); CC10; CCSP; UGB; SCGB1A1 |
| Immunogen | Recombinant Protein |
| Location | Secreted |
| Accession | P11684 |
| Clone Number | SDT-2736-46 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu |
| Positive Sample | BxPC-3 |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu |
| IHC-P | 1:2000 | Hu |
| IF | 1:200 | Hu |
Background
Uteroglobin, also known as secretoglobin 1A1 or blastokinin, is a small, 70–77 amino acid, disulfide-linked homodimeric protein that is secreted by the Clara (non-ciliated bronchiolar exocrine) cells of the pulmonary airways, the epithelial cells of the endometrium and the prostate, and is found in high concentrations in the uterine fluid of rabbits and other mammals during early pregnancy, where it functions as a potent anti-inflammatory, immunomodulatory, and anti-fibrotic agent by binding and sequestering hydrophobic ligands such as phospholipids, prostaglandins, and the lipid-derived aldehyde 4-hydroxy-2-nonenal, thereby protecting tissues from oxidative, allergic, and inflammatory damage, and has been implicated in the regulation of blastocyst implantation, angiogenesis, and tumor suppression through its ability to inhibit the transcription factor NF-κB and to prevent the activation of the NLRP3 inflammasome, making it a promising therapeutic target for respiratory, cardiovascular, renal, and neoplastic diseases.
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Exchange/Return Notes
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