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Description
SLAMF1/SLAM/CD150 His Tag Protein, MouseProduct Specification Species Mouse Synonyms CDw150,SLAM,IPO 3 Accession Q9QUM4 1 Amino Acid Sequence Thr25 Pro242, with C terminal His Tag Expression System HEK293 Molecular Weight 40 55kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | CDw150,SLAM,IPO-3 |
| Accession | Q9QUM4-1 |
| Amino Acid Sequence | Thr25-Pro242, with C-terminal His Tag |
| Expression System | HEK293 |
| Molecular Weight | 40-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Castro, A.G. et al. (1999) J. Immunol. 163:5860. 2.Cocks, B.G. et al. (1995) Nature 376:260. 3.Wang, N. et al. (2004) J. Exp. Med. 199:1255. 4.Hahm, B. et al. (2004) Virology 323:292. 5.Nanda, N. et al. (2005) Blood 106:3028. 6.Kiel, M.J. et al. (2005) Cell 121:1109. |
Background
The type I transmembrane glycoprotein Signaling Lymphocytic Activation Molecule (SLAM), also known as CD150, is the prototypic member of the SLAM subgroup of the CD2 protein family. Alternate splicing generates an isoform with a substituted cytoplasmic domain. SLAM is expressed on T cells, B cells, thymocytes, macrophages, dendritic cells, platelets, and hematopoietic stem cells. It is up‑regulated on activated B cells and CD4+ and CD8+ T cells, although it is down‑regulated on Th2 polarized cells. SLAM interacts homophilically with low affinity, and this interaction induces a Th0/Th1 response characterized by clonal expansion, production of IFN-gamma, and increased cytolytic activity of CD8+ T cells. SLAM ligation also promotes B cell activation, allergen-induced eosinophil and mast cell activation, NKT cell development, and the microbicidal response of macrophages to Gram negative bacteria. In humans, SLAM functions as a cellular entry receptor for measles virus.
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