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Description
Alexa Fluor® 647 Mouse Anti-Human CD135 Antibody (S-3176)Product Specification Host Mouse Antigen CD135 Synonyms Receptor type tyrosine protein kinase FLT3; FL cytokine receptor; Fetal liver kinase 2 (FLK 2); Fms like tyrosine kinase 3 (FLT 3); Stem cell tyrosine kinase 1 (STK 1); FLK2; STK1; FLT3 Location Membrane Accession P36888 Clone Number S 3176 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample THP 1 Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa
Product Specification
| Host | Mouse |
| Antigen | CD135 |
| Synonyms | Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2 (FLK-2); Fms-like tyrosine kinase 3 (FLT-3); Stem cell tyrosine kinase 1 (STK-1); FLK2; STK1; FLT3 |
| Location | Membrane |
| Accession | P36888 |
| Clone Number | S-3176 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | THP-1 |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD135, also known as FLT3 (Fms-like tyrosine kinase 3), is a class III receptor tyrosine kinase that plays a critical role in the regulation of hematopoiesis by promoting the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells upon binding to its ligand FLT3L; upon activation, CD135 undergoes dimerization and trans-phosphorylation, triggering downstream signaling cascades such as RAS/MAPK and PI3K/AKT pathways, which are essential for lymphoid lineage development and dendritic cell differentiation, while mutations—especially internal tandem duplications (FLT3-ITD)—lead to constitutive kinase activity, contributing to oncogenesis, particularly in acute myeloid leukemia (AML), where it is associated with poor prognosis and targeted by specific kinase inhibitors.
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