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Description
Rat Anti-Mouse CD192 Antibody (S-R731)Product Specification Host Rat Antigen CD192 Synonyms C C chemokine receptor type 2; C C CKR 2; CC CKR 2; CCR 2; CCR2; JE FIC receptor; MCP 1 receptor; Cmkbr2 Location Cell membrane Accession P51683 Clone Number S R731 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample BALB c mouse bone marrow Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4
Product Specification
| Host | Rat |
| Antigen | CD192 |
| Synonyms | C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; JE/FIC receptor; MCP-1 receptor; Cmkbr2 |
| Location | Cell membrane |
| Accession | P51683 |
| Clone Number | S-R731 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse bone marrow |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD192, also known as CCR2, is a seven-transmembrane, G-protein-coupled receptor that belongs to the beta chemokine receptor family. It is primarily expressed on monocytes, macrophages, basophils, dendritic cells, and some T cells. CD192 acts as a receptor for several chemokines, including monocyte chemoattractant protein-1 (MCP-1/CCL2), MCP-2/CCL8, MCP-3/CCL7, and MCP-4/CCL13. This receptor plays a crucial role in mediating monocyte chemotaxis and is involved in various inflammatory responses, such as the recruitment of monocytes into tissues during atherosclerosis, rheumatoid arthritis, and tumor formation. Additionally, CD192 has been implicated in the pathogenesis of certain cancers, where it controls the recruitment of activated macrophages that can either promote tumor cytotoxicity or inhibit tumor growth.
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Exchange/Return Notes
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