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Description
INPP4B Recombinant Rabbit mAb (S-3210-62)Product Specification Host Rabbit Antigen INPP4B Synonyms Inositol polyphosphate 4 phosphatase type II; Type II inositol 3,4 bisphosphate 4 phosphatase Immunogen Synthetic Peptide Location Cytoplasm Accession O15327 Clone Number S 3210 62 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample A204, MCF7 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | INPP4B |
| Synonyms | Inositol polyphosphate 4-phosphatase type II; Type II inositol 3,4-bisphosphate 4-phosphatase |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | O15327 |
| Clone Number | S-3210-62 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | A204, MCF7 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:100-1:250 | Hu |
Background
INPP4B (inositol polyphosphate 4-phosphatase type II) is a lipid phosphatase that selectively dephosphorylates PI(3,4)P₂ to PI(3)P, thereby acting as a brake on the PI3K/AKT signaling cascade by limiting AKT plasma-membrane recruitment and activation; through this mechanism it functions context-dependently as either a tumor suppressor—restraining proliferation, survival and chemoresistance in breast, prostate, gastric and nasopharyngeal cancers—or, paradoxically, as an oncogenic facilitator via SGK3 activation in subsets of melanoma, colon cancer and AML, while in male germ cells it safeguards DNA integrity and mitochondrial function during spermiogenesis.
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Exchange/Return Notes
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