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Description
IL-18 Protein, HumanProduct Specification Species Human Antigen IL 18 Synonyms IGIF, IL 18, IL1F4 Accession Q14116 Amino Acid Sequence Tyr37 Asp193 Expression System E. coli Molecular Weight 18 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 200mM NaCl, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after
Product Specification
| Species | Human |
| Antigen | IL-18 |
| Synonyms | IGIF, IL-18, IL1F4 |
| Accession | Q14116 |
| Amino Acid Sequence | Tyr37-Asp193 |
| Expression System | E.coli |
| Molecular Weight | 18 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 200mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. Acta Biochim Pol 2016;63(1):59-63. Epub 2016 Feb 17. |
Background
Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune response. In the milieu of IL-12 or IL-15, IL-18 is a potent inducer of IFN-gamma in natural killer (NK) cells and CD4 T helper (Th) 1 lymphocytes. However, IL-18 also modulates Th2 and Th17 cell responses, as well as the activity of CD8 cytotoxic cells and neutrophils, in a host microenvironment-dependent manner. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. Recently, IL-18 has also been shown to execute specific effects in pancreatic diseases, including acute and chronic pancreatitis, as well as pancreatic cancer.
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