E-Selectin/CD62E His Tag Protein, Cynomolgus
SKU: 73272109353

E-Selectin/CD62E His Tag Protein, Cynomolgus

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Description

E-Selectin/CD62E His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM 1, SELE, Selectin E, CD62 Antigen Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2 Accession XP_005539998. 2 Concentration 95% by SDS PAGE & SEC HPLC Amino Acid Sequence Trp22 Pro556 with His Tag at the C Terminus

Product Specification


Species Cynomolgus
Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM-1, SELE, Selectin E, CD62 Antigen-Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte-Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2
Accession XP_005539998.2
Concentration >95% by SDS-PAGE & SEC-HPLC
Amino Acid Sequence

Trp22-Pro556 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight

90-110kDa (Reducing)

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Liu ZJ, Tian R, An W, Zhuge Y, Li Y, Shao H, et al.. Identification ofE-selectin as a novel target for the regulation of post-natalneovascularization: implications for diabetic wound healing. Ann Surg. (2010)252:625–34.

Background

E-Selectin, officially known as Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1) or CD62E, is a member of the Selectin family of cell surface glycoproteins with a molecular weight ranging from 107 to 115 kDa. This cell adhesion molecule plays a pivotal role in inflammation and neovascularization, particularly in wound healing and ischemic areas.
Upon tissue injury, the release of cytokines and chemokines, such as stromal cell-derived factor 1α (SDF-1α), triggers the local expression of membrane-bound E-Selectin on endothelial cells. Concurrently, it induces the expression of systemic reciprocal E-Selectin ligands on endothelial progenitor cells (EPCs) within the bone marrow, mediated by the C-X-C motif chemokine receptor 4 (CXCR4).
E-Selectin is transiently expressed on vascular endothelial cells in response to cytokines like IL-1 beta and TNF-alpha, peaking at 4 hours post-activation and decaying by 24 hours. This cell surface glycoprotein is integral to immune cell adhesion, specifically by interacting with SELPLG/PSGL1 on blood neutrophils, which facilitates their adhesion to cytokine-activated endothelium. E-Selectin may also contribute to capillary morphogenesis.
During inflammation, E-Selectin mediates the attachment of flowing leukocytes to the blood vessel wall by binding to E-Selectin ligands present on leukocytes. These initial interactions are dynamic, allowing leukocytes to roll along the vascular endothelium in the direction of blood flow. Subsequently, stronger interactions involving ICAM-1 and VCAM-1 lead to the extravasation of white blood cells through the blood vessel wall and into the extracellular matrix of surrounding tissues.

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SKU: 73272109353

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Verified Purchase
Mom2MKLx2
Whiting, US
★★★★★ 2
Sad
Pattern Name: Strawberry
The outer part is good quality, the removable inside didn't last a day
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 29, 2026
A
Amazon customer
Port Orchard, US
★★★★★ 3
Didn’t hold up for more than a minute but the silicone strawberry by itself is durable.
Pattern Name: Strawberry, Pattern Name: Strawberry
Our best dog toy reviewer, a cattle dog mix, gave this toy a big thumbs up ONLY because she could demolish it in seconds. Not minutes, but seconds. The toy has a pouch stuffed into a silicone toy strawberry. The pouch is really stuffed in well, so much so that I couldn’t remove it, but she sure did! In about a minute all that was left was the dismembered strawberry “leaves” and a silicone strawberry which, oddly enough, she seems to enjoy. The silicone strawberry seems quite durable by itself. The toy is brightly colored and small in size. This not a durable toy unless you have a dog that is not an aggressive chewer, but for us, it is not recommended.
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Reviewed in the United States on March 15, 2026
T
Texas Pet Company
Charlottesville, US
★★★★★ 4
Good for larger treats, not small ones
Pattern Name: Carrot, Pattern Name: Carrot
Our dog loves this treat toy. It has been very durable as far as the rubber part goes but the cloth carrot insert not so much, that got torn apart pretty quickly. Also this works for bigger treats, but once the cloth carrot was destroyed, there was no way to keep small treats from just falling out. Now we use it to stick larger chew sticks in the holes and it works to help her keep it in place while chewing.
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Reviewed in the United States on May 11, 2026
K
KRR
Lake Worth, US
★★★★★ 5
Dogs love these treat toys
Pattern Name: Strawberry, Pattern Name: Strawberry
I have big dogs who live for treats and love to play puzzle games to find treats. You can stuff these toys with small treats which gives your dog a mental challenge while working to figure out how to get them out. The quality of these toys are great but durability with big dogs will be short lived. The strawberry green top immediately was de-stuffed while dog was looking for more hidden treats. The corn husk seems to be more challenging for them to get the treats out. However my smarter dog was determined and eventually reaped the rewards. I would recommend these toys for dogs who will not rip them apart.... but really is there any pup who doesn't enjoy de-stuffing a stuffie squeek toy?
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Reviewed in the United States on May 14, 2026
K
Verified Purchase
K. Gardner
Grantham, US
★★★★★ 5
Great feeder for high energy puppy!
Size: Large, Color: Blue
I have a 50lb high energy puppy. She is not a fast eater, BUT she loves this activity and it gives me about 30 minutes of uninterrupted bliss. It took about 10 minutes to demonstrate to help her get the hang of it. She will sit, spin the barrel with her paw, then sniff every divider, only open the ones with her food, and then restart the process. It is sturdy and stays on the floor as she paws and pushes. It might move a little, but not far. This is my favorite puzzle toy by far and I love that it is "hard" enough to keep her occupied but not enough that she gets frustrated and doesn't want to do it.
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Reviewed in the United States on June 7, 2026

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