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Description
Human IL-2 OneStep ELISA KitProduct Specification Antigen IL 2 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 2 to 8 C as supplied. Kit Precision Intra assay: 5. 9% Inter assay: 8. 5% Sample type Cell culture supernatant, Serum, Plasma Assay type Sandwich (quantitative) Sensitivity 5 pg ml Range 15. 6 pg ml 1000 pg ml Recovery Cell culture supernatant 112% ; Serum 103%; Plasma 118% Assay time 60 minutes
Product Specification
| Antigen | IL-2 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage |
2 to 8 °C as supplied. |
Kit
| Precision |
Intra-assay: 5.9%； |
| Sample type |
Cell culture supernatant, Serum, Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 5 pg/ml |
| Range | 15.6 pg/ml - 1000 pg/ml |
| Recovery |
Cell culture supernatant 112% ; Serum 103%; Plasma 118% |
| Assay time | 60 minutes |
| Species reactivity | human |
| CROSS REACTIVITY | / |
| INTERFERENCE | / |
| NIBSC convert |
The dose response curve of the International Standard (86/500) parallels the OneStep standard curve. To convert sample values obtained with the kit to approximate NIBSC (86/500) units, use the following equation: NIBSC (86/500) approximate value (IU/mL) = 0.014 x OneStep Human IL-2 value (pg/mL). |
Background
Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotropic hormone that is instrumental in the body natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-Regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self-antigens", which could result in "autoimmunity". T-Regs do this by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.
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