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Description
SLC25A51 Recombinant Rabbit mAb (S-2070-74)Product Specification Host Rabbit Antigen SLC25A51 Synonyms Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51; Mitochondrial NAD(+) transporter SLC25A51; Mitochondrial carrier triple repeat protein 1; Solute carrier family 25 member 51; MCART1 Immunogen Synthetic Peptide Location Mitochondrion Accession Q9H1U9 Clone Number S 2070 74 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms Positive Sample HT
Product Specification
| Host | Rabbit |
| Antigen | SLC25A51 |
| Synonyms | Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51; Mitochondrial NAD(+) transporter SLC25A51; Mitochondrial carrier triple repeat protein 1; Solute carrier family 25 member 51; MCART1 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | Q9H1U9 |
| Clone Number | S-2070-74 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Positive Sample | HT-29, SW480, HCT 116, SW620, LoVo |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu, Ms |
Background
SLC25A51, also known as MCART1, is a mammalian mitochondrial NAD+ transporter that plays a crucial role in cellular metabolism and energy production. Located in the inner mitochondrial membrane, it facilitates the transport of NAD+ into mitochondria, which is essential for maintaining mitochondrial NAD+/NADH ratios and supporting mitochondrial respiration. SLC25A51 is involved in various cellular processes, including the regulation of the AKT/mTOR signaling pathway and proline synthesis, which are critical for cell proliferation. Additionally, its expression is regulated by fasting and circadian rhythms, and it is necessary for sustaining the activity of the mitochondrial deacetylase SIRT3. Recent studies have also shown that SLC25A51 is upregulated in various cancers and promotes tumor growth by maintaining mitochondrial acetylation homeostasis.
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