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Description
B7-H3 Recombinant Rabbit mAb,PBS Only (SDT-1333-8)Product Specification Host Rabbit Antigen B7 H3 Synonyms CD276 antigen, 4Ig B7 H3, B7 homolog 3 (B7 H3), Costimulatory molecule, CD276 Immunogen Recombinant Protein Location Membrane Accession Q5ZPR3 Clone Number SDT 1333 8 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from
Product Specification
| Host | Rabbit |
| Antigen | B7-H3 |
| Synonyms | CD276 antigen, 4Ig-B7-H3, B7 homolog 3 (B7-H3), Costimulatory molecule, CD276 |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | Q5ZPR3 |
| Clone Number | SDT-1333-8 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:100 |
Background
B7-H3 is a 316 amino acid-long type I transmembrane protein, existing in two isoforms determined by its extracellular domain. In humans it consists of one pair (2Ig-B7-H3) or two identical pairs (4Ig-B7-H3) due to exon duplication. B7-H3 mRNA is expressed in most normal tissues. In contrast, B7-H3 protein has a very limited expression on normal tissues because of its post-transcriptional regulation by microRNAs. However, B7-H3 protein is expressed at high frequency on many different cancer types (60% of all cancers). In non-malignant tissues, B7-H3 has a predominantly inhibitory role in adaptive immunity, suppressing T cell activation and proliferation. In malignant tissues, B7-H3 is an immune checkpoint molecule that inhibits tumor antigen-specific immune responses. B7-H3 also possesses non-immunological pro-tumorigenic functions such as promoting migration, invasion, angiogenesis, chemoresistance, epithelial-to-mesenchymal transition, and affecting tumor cell metabolism.
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