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Description
FGF-basic(154aa) Heat Stable Protein, HumanProduct Specification Species Human Synonyms bFGF, FGF 2, Heparin binding growth factor 2, Basic fibroblast growth factor, FGFB, HBGF 2, FGF2, Fibroblast Growth Factor 2 (Basic) Accession P09038 Amino Acid Sequence Ala135 Ser288 with proprietary amino acid modifications Expression System E. coli Molecular Weight 14 15 kDa (Reducing) Purity >95% by SDS PAGE & HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized
Product Specification
| Species | Human |
| Synonyms | bFGF, FGF-2, Heparin-binding growth factor 2, Basic fibroblast growth factor, FGFB, HBGF-2, FGF2, Fibroblast Growth Factor 2 (Basic) |
| Accession | P09038 |
| Amino Acid Sequence | Ala135-Ser288 with proprietary amino acid modifications |
| Expression System | E.coli |
| Molecular Weight | 14-15 kDa (Reducing) |
| Purity | >95% by SDS-PAGE & HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. J Biol Chem. 1996 Jun 21;271(25):15292-7. |
Background
Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in remodeling damaged tissue, such as ulcer healing, vascular repair, traumatic brain injury (TBI). bFGF is a critical component of human embryonic stem cell culture medium. In addition, bFGF protein is a heparin-binding cationic protein involved in a variety of pathological conditions including angiogenesis and solid tumour growth. Thus, bFGF is regarded as a target for cancers chemopreventive and therapeutic strategies.
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