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Description
PE Rat Anti-Mouse MERTK Antibody (S-R603)Product Specification Host Rat Antigen MERTK Synonyms Tyrosine protein kinase Mer; Proto oncogene c Mer; Receptor tyrosine kinase MerTK; Mer; Mertk Location Cell membrane Accession Q60805 Clone Number S R603 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse peritoneal exudates cells Purification Protein G Concentration 0. 2 mg ml Conjugation PE Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3%
Product Specification
| Host | Rat |
| Antigen | MERTK |
| Synonyms | Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; Mer; Mertk |
| Location | Cell membrane |
| Accession | Q60805 |
| Clone Number | S-R603 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse peritoneal exudates cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
MERTK, also known as MER proto-oncogene tyrosine kinase, is a type I receptor tyrosine kinase and a member of the TAM (TYRO3, AXL, and MERTK) family. It plays crucial roles in various physiological processes, including cell survival, migration, differentiation, and the phagocytosis of apoptotic cells. MERTK is activated by binding to ligands such as GAS6 and PROS1, which triggers autophosphorylation and downstream signaling through pathways like PI3K/AKT, MAPK, and STAT. This receptor is highly expressed in immune cells like macrophages and dendritic cells, and its activation promotes an anti-inflammatory M2 phenotype in macrophages. In the retina, MERTK is essential for the phagocytosis of rod outer segment fragments by the retinal pigment epithelium. Abnormal expression of MERTK has been linked to several diseases, including retinitis pigmentosa and various cancers, making it a potential therapeutic target.
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