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Description
CaMKII alpha Recombinant Rabbit mAb (S-2451-54)Product Specification Host Rabbit Antigen CaMKII alpha Synonyms Calcium calmodulin dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK II subunit alpha; CAMKA; KIAA0968; CAMK2A Immunogen Synthetic Peptide Location Synapse Accession Q9UQM7 Clone Number S 2451 54 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample SH SY5Y, U 87 MG, mouse brain, rat brain Predicted Reactivity
Product Specification
| Host | Rabbit |
| Antigen | CaMKII alpha |
| Synonyms | Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMKA; KIAA0968; CAMK2A |
| Immunogen | Synthetic Peptide |
| Location | Synapse |
| Accession | Q9UQM7 |
| Clone Number | S-2451-54 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | SH-SY5Y, U-87 MG, mouse brain, rat brain |
| Predicted Reactivity | Or, Ck, Pg, Xe, Bv, Zf, Rb |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
CaMKII alpha is a major isoform of Ca²⁺/calmodulin-dependent protein kinase II, predominantly expressed in the mammalian central nervous system, with high abundance in brain regions associated with learning and memory, such as the hippocampus and cerebral cortex. This protein consists of multiple catalytic domains, regulatory domains, and an oligomerization domain, typically forming 12-mer homo- or hetero-oligomeric complexes. Its core function is to decode calcium signals: when intracellular Ca²⁺ levels rise, the Ca²⁺/calmodulin complex binds to CaMKII alpha, relieving autoinhibition and activating its kinase activity. This allows it to phosphorylate various substrates, including AMPA and NMDA receptors, thereby regulating synaptic plasticity and neuronal signaling. A key characteristic is its ability to undergo "autophosphorylation" – autophosphorylation at Thr286 enables CaMKII alpha to retain partial activity even after the Ca²⁺ signal dissipates. This mechanism is considered a molecular "memory switch," crucial for long-term potentiation (LTP) and the formation of learning and memory. Furthermore, dysregulated expression or altered activity of CaMKII alpha is closely associated with various neurological disorders, such as epilepsy and Alzheimer's disease.
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