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Description
PAD4 Recombinant Rabbit mAb (SDT-2416-3)Product Specification Host Rabbit Antigen PAD4 Synonyms Protein arginine deiminase type 4; Peptidylarginine deiminase IV; Protein arginine deiminase type IV; Pad4; Pdi4; Padi4 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q9Z183 Clone Number SDT 2416 3 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | PAD4 |
| Synonyms | Protein-arginine deiminase type-4; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV; Pad4; Pdi4; Padi4 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q9Z183 |
| Clone Number | SDT-2416-3 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:500-1:1000 | Ms, Rt |
Background
Protein-arginine deiminase type-4 (PAD4) is a human enzyme encoded by the PADI4 gene, located on the short arm of chromosome 1. PAD4 is a calcium-dependent enzyme that catalyzes the conversion of arginine residues to citrulline in proteins, a process known as citrullination. It is primarily expressed in white blood cells such as granulocytes and monocytes, and can also be found in the nucleus. PAD4 plays a crucial role in the formation of neutrophil extracellular traps (NETs), which are involved in the immune response against pathogens. However, excessive PAD4 activity and NET formation have been implicated in various diseases, including rheumatoid arthritis, multiple sclerosis, cancer, and cardiovascular diseases. PAD4 also influences gene expression by deimininating histones, and its dysregulation can impact cellular processes like apoptosis and differentiation. Due to its involvement in multiple disease pathways, PAD4 has become a promising target for therapeutic interventions.
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