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Description
Phospho-TGF β Receptor I(Ser165) Recombinant Rabbit mAb (S-1896-21)Product Specification Host Rabbit Antigen Phospho TGF Receptor I(Ser165) Synonyms TGF beta receptor type 1; TGFR 1; Activin A receptor type II like protein kinase of 53kD; Activin receptor like kinase 5 (ALK 5; ALK5); Serine threonine protein kinase receptor R4 (SKR4); TGF beta type I receptor; Transforming growth factor beta receptor type I (TGF beta receptor type I; TbetaR I); ALK5; SKR4; TGFBR1 Immunogen Synthetic Peptide Location Cell membrane
Product Specification
| Host | Rabbit |
| Antigen | Phospho-TGF β Receptor I(Ser165) |
| Synonyms | TGF-beta receptor type-1; TGFR-1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5 (ALK-5; ALK5); Serine/threonine-protein kinase receptor R4 (SKR4); TGF-beta type I receptor; Transforming growth factor-beta receptor type I (TGF-beta receptor type I; TbetaR-I); ALK5; SKR4; TGFBR1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P36897 |
| Clone Number | S-1896-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa treated with 100 ng/ml Calyculin A for 30 minutes, Serum-starved NIH/3T3 treated with 100 nM Calyculin A for 30 minutes |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu, Ms |
| ICC | 1:500 | Hu |
Background
Phospho-TGF β Receptor I (Ser165) is a phosphorylated form of the Transforming Growth Factor-beta Receptor Type I (TGFBR1), a transmembrane serine/threonine kinase that plays a crucial role in transmitting TGF-beta signals from the cell surface to the cytoplasm. This receptor forms a complex with TGF-beta type II receptors and is activated upon binding to TGF-beta ligands, leading to the phosphorylation of downstream SMAD proteins, which then regulate gene transcription involved in cell cycle control, differentiation, wound healing, and immune responses. The phosphorylation at Ser165 is particularly important for its activation and signaling, and this site is often targeted by antibodies for research applications such as Western blotting, immunohistochemistry, and immunofluorescence.
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