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Description
CHMP1a Recombinant Rabbit mAb (S-1651-159)Product Specification Host Rabbit Antigen CHMP1a Synonyms Charged multivesicular body protein 1a; Chromatin modifying protein 1a (CHMP1a); Vacuolar protein sorting associated protein 46 1 (Vps46 1; hVps46 1); CHMP1; KIAA0047; PCOLN3; PRSM1; CHMP1A Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Endosome Accession Q9HD42 Clone Number S 1651 159 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive
Product Specification
| Host | Rabbit |
| Antigen | CHMP1a |
| Synonyms | Charged multivesicular body protein 1a; Chromatin-modifying protein 1a (CHMP1a); Vacuolar protein sorting-associated protein 46-1 (Vps46-1; hVps46-1); CHMP1; KIAA0047; PCOLN3; PRSM1; CHMP1A |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Endosome |
| Accession | Q9HD42 |
| Clone Number | S-1651-159 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | 293T, LNCaP, HepG2, HeLa, C2C12, RAW264.7, PC-12 |
| Predicted Reactivity | Or, Zf, Xe |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:50 | Hu |
| ICC | 1:500 | Hu, Ms, Rt |
Background
CHMP1a (Charged Multivesicular Body Protein 1a) is a protein encoded by the CHMP1A gene in humans and belongs to the ESCRT-III (Endosomal Sorting Complex Required for Transport) family. It plays a crucial role in the formation and sorting of multivesicular bodies (MVBs), which are involved in the degradation of proteins in lysosomes. CHMP1a is also known as Chromatin Modifying Protein 1A and has been identified as a novel tumor suppressor gene, particularly in pancreatic and embryonic kidney tumor cells. It can inhibit cell proliferation and tumor growth by regulating the expression of proteins like p53. Additionally, CHMP1a interacts with other proteins such as SKD1 and LIP5, which are involved in the endosomal sorting process.
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