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Description
Alexa Fluor 647-Labeled Syndecan-1/CD138 His Tag Protein, HumanProduct Specification Species Human Synonyms Syndecan Proteoglycan 1,CD138,SYND1,SDC,Syndecan 1,SDC1 Accession P18827 Amino Acid Sequence Gln23 Gly254 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 45kDa Conjugation Alexa Fluor 647 Tag His Tag Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months from date of receipt, lyophilized powder stored at 20 to 80. 3 months, 20 to 80 under sterile
Product Specification
| Species | Human |
| Synonyms | Syndecan Proteoglycan 1,CD138,SYND1,SDC,Syndecan-1,SDC1 |
| Accession | P18827 |
| Amino Acid Sequence | Gln23-Gly254 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 45kDa |
| Conjugation | Alexa Fluor® 647 |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1、Palaiologou M. et al. (2014) CD138 (syndecan-1) expression in health and disease. Histol Histopathol. 29(2): 177-189. |
Background
CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans. CD138 is significant for cell-cell and cell-matrix interactions. In adult human tissues, CD138 is predominantly expressed in epithelial cells and plasmacytes. CD138 immunoexpression is altered in a wide spectrum of benign inflammatory, infectious and fibrotic diseases (colitis, allergic contact dermatitis, fibrosis of various organs, etc) and diabetes mellitus type II. Furthermore, CD138 is involved in molecular pathways that are deregulated during carcinogenesis and are related to cell proliferation, apoptosis, angiogenesis, tumour invasion and metastasis.CD138 tumour cell and stromal immunoexpression is modified in various types of cancer, and is frequently correlated with clinicopathological parameters and patients' prognosis. The soluble form of CD138 may be used as a prognostic serum biomarker with promising results in respiratory tract carcinomas. CD138 plays a crucial role in carcinogenesis and is an attractive target for anticancer treatment with heparanase inhibitors and anti-CD138 antibodies for immunotherapy.
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