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Description
CSF-1R Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen CSF 1R Synonyms Macrophage colony stimulating factor 1 receptor; CSF 1 receptor (CSF 1 R; CSF 1R; M CSF R); Proto oncogene c Fms; CD115; Csfmr; Fms; Csf1r Immunogen Recombinant Protein Location Cell membrane Accession P09581 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Ms Positive Sample RAW264. 7, mouse spleen Purification Immunogen Affinity Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | CSF-1R |
| Synonyms | Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor (CSF-1-R; CSF-1R; M-CSF-R); Proto-oncogene c-Fms; CD115; Csfmr; Fms; Csf1r |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P09581 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms |
| Positive Sample | RAW264.7, mouse spleen |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:200 | Ms |
Background
Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS). CSF1R is a receptor that can be activated by two ligands: colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34). CSF1R is highly expressed in myeloid cells, and CSF1R signaling is necessary for the survival, proliferation, and differentiation of many myeloid cell types in vivo and in vitro. CSF1R signaling is involved in many diseases and is targeted in therapies for cancer, neurodegeneration, and inflammatory bone diseases.
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Exchange/Return Notes
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