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Description
S-RMab®HDAC6 Recombinant Rabbit mAb (S-R338)Product Specification Host Rabbit Antigen HDAC6 Synonyms Histone deacetylase 6, HD6, Histone deacetylase mHDA2, Tubulin lysine deacetylase HDAC6 Location Cytoplasm, Nucleus Accession Q9Z2V5 Clone Number S R338 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | HDAC6 |
| Synonyms | Histone deacetylase 6, HD6, Histone deacetylase mHDA2, Tubulin-lysine deacetylase HDAC6 |
| Location | Cytoplasm, Nucleus |
| Accession | Q9Z2V5 |
| Clone Number | S-R338 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:500 | |
| ICC | 1:100 | |
| ICFCM | 1:50 |
Background
Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene. HDAC6 belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains that appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. Since HDAC6 is dysregulated and/or implicated in several cancers and neurodegenerative disorders, pharmacological inhibition of this specific enzyme holds great therapeutic potential and could also limit side effects associated with pan-inhibitors of multiple HDAC enzymes.
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