SKU: 77743656767

Mouse Anti-Rat CD45R Antibody (S-3303)

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Description

Mouse Anti-Rat CD45R Antibody (S-3303)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; Ptprc Location Cell membrane, Synapse Accession P04157 Clone Number S 3303 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Rt Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date

Product Specification


Host Mouse
Antigen CD45
Synonyms Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; Ptprc
Location Cell membrane, Synapse
Accession P04157
Clone Number S-3303
Antibody Type Mouse mAb
Isotype IgG2b,k
Application FCM
Reactivity Rt
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Background

CD45R is a critical splice variant of the CD45 protein, belonging to the receptor-type protein tyrosine phosphatase (RPTP) family. It is primarily expressed on the surface of B cells, monocytes, and certain T cell subsets. As a transmembrane glycoprotein, its extracellular region contains domains (A, B, C) encoded by variable exons, forming diverse isoforms (e.g., CD45RA, CD45RB). These domain variations influence glycosylation patterns and ligand-binding properties. The core function of CD45R lies in its intracellular phosphatase domain, which specifically dephosphorylates the C-terminal inhibitory tyrosine residues of Src family kinases (such as Lck and Fyn). This action positively regulates the initiation and activation threshold of lymphocyte receptor signaling pathways, playing a vital role in B cell development, activation, and the fine-tuning of immune responses. Changes in its expression pattern often serve as markers for lymphocyte differentiation and activation status (e.g., CD45RA+ denotes naive T cells), holding significant value in immunology research and the clinical diagnosis of immune-related diseases.

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SKU: 77743656767

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Sarah A
Massapequa, US
★★★★★ 5
Great fun for my small pup
Color: Egg Balls
My 15lb Pom loves anything that sqweeks so these little eggs are perfect for him. They are fun to throw since they bounce in all different directions. Considering how many you get it's worth purchasing
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Reviewed in the United States on January 31, 2026
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Casandra L.
Waukegan, US
★★★★★ 5
dogs have fun with them
Color: Smile Face Balls
They are a cute product. Do not give to large dogs. Made for tiny breeds. I dog sit and the dogs who are allowed to play with them go nuts when I get them out and give a sqeeze. The toys are holding up well too.
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Reviewed in the United States on April 22, 2026
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J_B_Cran
Lake Worth, US
★★★★★ 5
Love.
Color: Pig Balls
My frenchies love these and large enough not to worry about choking. Also the squeaker lasts longer than most of their latex toys so good or bad, I think it’s good.
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Reviewed in the United States on April 21, 2026
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vvickib54
Whiting, US
★★★★★ 5
Puppy Favorite!
Color: Funny Face Balls
Just the right size for a cocker puppy to fit in her mouth (3 mos. old) and squeak. She will do this indefinitely if I let her, lol! Seems to be very satisfying for her. I can only take so much of it but she loves them. Also bounces erratically when you toss it which she loves.
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Reviewed in the United States on August 25, 2025
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JerseyGirl
New York, US
★★★★★ 5
Perfect toy for an active dog!
Color: Large size (7.9")
My dog absolutely loves this ball with handles! It’s quickly become one of his favorite toys, and he gets excited every time we bring it out to play. The vibrant colors are a huge plus—they make it super easy to spot in the grass, which saves a lot of time during outdoor play sessions. The handles are great for interactive play too, especially for tugging and tossing. I’m really impressed with how well it’s holding up. Even with constant pulling, tugging, and rough use, it’s remained durable and hasn’t shown any signs of wearing out. Overall, I’m very happy with this purchase—and if my dog could write reviews, it would definitely get his paw stamp of approval! 🐾
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Reviewed in the United States on May 24, 2026

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