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Description
FIS1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen FIS1 Synonyms Mitochondrial fission 1 protein; FIS1 homolog (hFis1); Tetratricopeptide repeat protein 11 (TPR repeat protein 11); TTC11 Immunogen Recombinant Protein Location Mitochondrion Accession Q9Y3D6 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, HeLa, Jurkat, HepG2, A431, EL4, PC 12, rat spleen, COS 7 Purification Immunogen Affinity
Product Specification
| Host | Rabbit |
| Antigen | FIS1 |
| Synonyms | Mitochondrial fission 1 protein; FIS1 homolog (hFis1); Tetratricopeptide repeat protein 11 (TPR repeat protein 11); TTC11 |
| Immunogen | Recombinant Protein |
| Location | Mitochondrion |
| Accession | Q9Y3D6 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, HeLa, Jurkat, HepG2, A431, EL4, PC-12, rat spleen, COS-7 |
| Purification | Immunogen Affinity |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, Mk |
Background
FIS1 (Mitochondrial Fission Protein 1) is a 17-kDa outer mitochondrial membrane protein that plays a central role in mitochondrial quality control by promoting organellar fission: under stress it recruits the GTPase DRP1 to form a constriction ring that severs mitochondria, while also inhibiting fusion proteins (MFN/OPA1), engaging mitophagy adaptors (TBC1D15/17) to clear damaged fragments, and interacting with BAP31 to amplify apoptotic signals, thereby governing mitochondrial morphology, energy metabolism, cell survival and—when dysregulated—tumorigenesis or neurodegeneration.
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