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Description
IL-19 Protein, MouseProduct Specification Species Mouse Antigen IL 19 Synonyms MDA1, NG. 1, ZMDA1, IL 10C Accession Q8CJ70 Amino Acid Sequence Leu25 Ala176 Expression System E. coli Molecular Weight 17kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability &
Product Specification
| Species | Mouse |
| Antigen | IL-19 |
| Synonyms | MDA1, NG.1, ZMDA1, IL-10C |
| Accession | Q8CJ70 |
| Amino Acid Sequence | Leu25-Ala176 |
| Expression System | E.coli |
| Molecular Weight | 17kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Robert Sabat, Elizabeth Wallace, Stefanie Endesfelder, Kerstin Wolk. IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases. Expert Opin Ther Targets. 2007 11(5):601-12. |
Background
IL-19 is member of the so-called IL-10 family of cytokines. This family also contains IL-10, an anti-inflammatory cytokine known of for a very long time, and six other mediators: IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B and IL-29. The members of the IL-10 family have the following features: clustering of their encoding genes, similar genomic structures, similar primary and secondary protein structures and use of similar receptor complexes. In fact, these nine proteins are encoded by genes that are found in the human genome in three clusters and have similar exon–intron structures. Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast.
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