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Description
ERAP1 Recombinant Rabbit mAb (S-2509-38)Product Specification Host Rabbit Antigen ERAP1 Synonyms Endoplasmic reticulum aminopeptidase 1; ARTS 1; Adipocyte derived leucine aminopeptidase (A LAP); Aminopeptidase PILS; Puromycin insensitive leucyl specific aminopeptidase (PILS AP); Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator; APPILS; ARTS1; KIAA0525 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession Q9NZ08 Clone Number S 2509 38 Antibody Type
Product Specification
| Host | Rabbit |
| Antigen | ERAP1 |
| Synonyms | Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase (A-LAP); Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase (PILS-AP); Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator; APPILS; ARTS1; KIAA0525 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | Q9NZ08 |
| Clone Number | S-2509-38 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | K562, A431, HDLM-2, HUVEC, Jurkat, HepG2, Ramos, mouse liver, mouse heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:2000 | Hu, Ms, Rt |
Background
ERAP1 (Endoplasmic Reticulum Aminopeptidase 1) is a zinc-dependent metalloaminopeptidase localized in the endoplasmic reticulum that plays a critical role in antigen processing by trimming N-terminal residues of peptides to optimize their length (8–10 amino acids) for loading onto MHC class I molecules, thereby shaping the immunopeptidome and influencing immune responses; it also modulates inflammation by cleaving cytokine receptors and is genetically associated with autoimmune diseases such as ankylosing spondylitis and Behçet’s disease, particularly in individuals carrying specific HLA alleles like HLA-B27 or HLA-B*51.
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Exchange/Return Notes
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